Issue 18, 2019

Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

Abstract

Copper(II) coordination complexes, 1 and 2, containing nonsteroidal anti-inflammatory drugs (NSAIDs) potently kill breast cancer stem cells (CSCs) and bulk breast cancer cells. Although detailed biological studies have been conducted to shed light on their mechanism of cytotoxicity, little is known about their molecular level mechanism of action. This biophysical study, aided by the preparation of a fluorophore-containing analogue, 3, reveals that the complexes operate by undergoing reduction to a copper(I) form and releasing the associated NSAIDs.

Graphical abstract: Biophysical analysis of cancer stem cell-potent copper(ii) coordination complexes

Supplementary files

Article information

Article type
Communication
Submitted
20 ربيع الأول 1440
Accepted
26 ربيع الثاني 1440
First published
26 ربيع الثاني 1440

Dalton Trans., 2019,48, 5892-5896

Biophysical analysis of cancer stem cell-potent copper(II) coordination complexes

P. Zheng, A. Eskandari, C. Lu, K. Laws, L. Aldous and K. Suntharalingam, Dalton Trans., 2019, 48, 5892 DOI: 10.1039/C8DT04706E

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