Issue 9, 2018

High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulations

Abstract

Effective adjuvants in anti-tumour vaccine formulations are very important in the development of new-generation vaccines. In this study, two layered double hydroxide (LDH) nanomaterial forms, i.e. nanoparticles (NPs) and nanosheets (NSs), were synthesised and examined as adjuvants to provoke the immune responses for anti-tumour purpose. Immunogen ovalbumin (OVA) delivered by both nanomaterials induced much stronger humoral and cell-medicated immune responses, together with an immune stimulant (TLR9 ligand CpG), as evidenced by higher levels of IgG1, IgG2a and interferon-γ. By comparison, LDH NSs showed higher activity to promote specific antibody responses than LDH NPs but with a similar cell-mediated immune response. The mice immunised with OVA-CpG vaccines formulated with both nanomaterials showed stronger inhibition of the inoculated tumour growth and had a longer survival. Altogether, these data indicate that LDH NPs and NSs can be used as potential nanoadjuvants for efficient protein-based anti-tumour vaccines.

Graphical abstract: High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulations

Supplementary files

Article information

Article type
Paper
Submitted
14 محرم 1439
Accepted
18 صفر 1439
First published
19 صفر 1439

Dalton Trans., 2018,47, 2956-2964

High adjuvant activity of layered double hydroxide nanoparticles and nanosheets in anti-tumour vaccine formulations

S. Yan, W. Gu, B. Zhang, B. E. Rolfe and Z. P. Xu, Dalton Trans., 2018, 47, 2956 DOI: 10.1039/C7DT03725B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements