Issue 80, 2018

Reactivity and properties of bis(chlorodifluoroacetyl) peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions

Abstract

We developed a practical chlorodifluoromethylation reaction mediated by diacyl peroxide generated in situ from chlorodifluoroacetic anhydride. Allylic and amino-chlorodifluoromethylations of alkenes proceeded well with the combination of this reagent, Cu(II) catalyst and a pyridine additive. Carbo- and aromatic chlorodifluoromethylations proceeded under metal-free conditions.

Graphical abstract: Reactivity and properties of bis(chlorodifluoroacetyl) peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions

Supplementary files

Article information

Article type
Communication
Submitted
07 ذو القعدة 1439
Accepted
03 محرم 1440
First published
04 محرم 1440

Chem. Commun., 2018,54, 11276-11279

Reactivity and properties of bis(chlorodifluoroacetyl) peroxide generated in situ from chlorodifluoroacetic anhydride for chlorodifluoromethylation reactions

S. Kawamura, C. J. Henderson, Y. Aoki, D. Sekine, S. Kobayashi and M. Sodeoka, Chem. Commun., 2018, 54, 11276 DOI: 10.1039/C8CC05905E

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