Issue 18, 2017

CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy

Abstract

Single or few-layered MoS2 nanosheets, as a novel class of 2D nanomaterials, have received tremendous attention due to their fantastic physical and chemical properties. Here, we fabricated MoS2–PEG–CpG with a small and uniform size as a multifunctional platform for photothermal enhanced immunotherapy. MoS2 nanosheets were fabricated by chemical exfoliation and further probe sonication. To realize MoS2-based adjuvant delivery, MoS2 nanosheets were functionalized with cytosine–phosphate–guanine (CpG) and polyethylene glycol (PEG) to form MoS2–PEG–CpG nanoconjugates. As an efficient nanocarrier with excellent near infrared-light (NIR) absorbing performance, MoS2–PEG–CpG significantly promotes CpG intracellular accumulation and the effect can be further enhanced by photothermal treatment. In addition, the enhanced uptake can stimulate the production of proinflammatory cytokines and remarkably elevate the immune response level. Finally, we found that MoS2–PEG–CpG could reduce the proliferative activity of cancer cells when co-cultured with a macrophage-like cell upon NIR irradiation, implying a novel strategy for multifunctional therapeutics against cancers.

Graphical abstract: CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy

Supplementary files

Article information

Article type
Paper
Submitted
01 جمادى الثانية 1438
Accepted
15 رجب 1438
First published
15 رجب 1438

Nanoscale, 2017,9, 5927-5934

CpG loaded MoS2 nanosheets as multifunctional agents for photothermal enhanced cancer immunotherapy

Q. Han, X. Wang, X. Jia, S. Cai, W. Liang, Y. Qin, R. Yang and C. Wang, Nanoscale, 2017, 9, 5927 DOI: 10.1039/C7NR01460K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements