Issue 69, 2016

Iron nitrate/TEMPO-catalyzed aerobic oxidative synthesis of quinazolinones from alcohols and 2-aminobenzamides with air as the oxidant

Abstract

A highly efficient, iron nitrate/TEMPO-catalyzed approach for the synthesis of quinazolinones has been achieved via a one-pot, tandem aerobic oxidative cyclization of primary alcohols with 2-aminobenzamides. This practical reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields with air as the terminal green oxidant. Thus, the present synthetic protocol provides an efficient and concise strategy for the synthesis of quinazolinones.

Graphical abstract: Iron nitrate/TEMPO-catalyzed aerobic oxidative synthesis of quinazolinones from alcohols and 2-aminobenzamides with air as the oxidant

Supplementary files

Article information

Article type
Paper
Submitted
03 شعبان 1437
Accepted
25 رمضان 1437
First published
29 رمضان 1437

RSC Adv., 2016,6, 65196-65204

Iron nitrate/TEMPO-catalyzed aerobic oxidative synthesis of quinazolinones from alcohols and 2-aminobenzamides with air as the oxidant

Y. Hu, L. Chen and B. Li, RSC Adv., 2016, 6, 65196 DOI: 10.1039/C6RA12164K

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