Black tea-theaflavins lower postprandial hyperglycemia by raising plasma GLP-1 and insulin levels in mice. Theaflavin-3′-gallate (TF2B) effectively activates GPR55, and promotes GLP-1 release via Ca2+/CaMKII and ERK1/2 pathways in STC-1 cells.
Aloe emodin attenuated motor and cognitive dysfunction in HD model mice. Aloe emodin decreased the level of the mutant huntingtin protein and inhibited CaMKII/Smad and TGF-β1/Smad signaling.
Here we have reported novel polymeric devices to control fluid flow using surface forces and capillary action to facilitate counter-diffusive, on-chip protein crystallization.
SMLC protects against atrial remodeling of AF by inhibiting oxidative stress through the mediation of the MsrA/p38 MAPK signaling pathway
Invasive non-typhoidal Salmonella (iNTS) are a growing bacterial threat due to their antimicrobial resistance. This work demonstrates that iNTS are susceptible to host-directed therapies that inhibit intracellular bacterial replication.