We developed a novel fluorescent indicator, TO-G-clamp, by conjugating a thiazole orange derivative with G-clamp, which identified unique RNA-binding small molecules missed by conventional indicators in fluorescent indicator displacement assay.
This review discusses developments in elemental mass spectrometry, atomic absorption, emission and fluorescence, XRF and LIBS, as applied to the analysis of specimens of clinical interest, foods and beverages. Sample preparation procedures and quality assurance are also included.
Recently developed CRISPR/Cas-based detection strategies, multiplex detection strategies by the combination of different CRISPR/Cas and challenges as well as prospects for tumor biomarker detection were comprehensively summarized and discussed.
Foodomics aids colorectal cancer management via diet and biomarkers, showing promise despite challenges.
SARS-CoV-2 infection leads to miRNA expression changes in body fluids of COVID-19 patients. This review summarizes data on miRNAs that change expression during COVID-19 and can potentially be used as biomarkers for COVID-19 and/or disease severity.