This review summarizes the most recent progress made in C–H bond activation-initiated spiroannulation reactions and their applications in the construction of structurally diverse and biologically valuable spirocyclic scaffolds.
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.
This review aims to collect advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years, and it is organized into thirteen sections depending on the different types of transformations involved.
An unprecedented [3+2] spiroannulation of 3,3-dimethyl-2-aryl-3H-indole with ynones/ynoates has been exemplified, furnishing architecturally ornamented C2-spiro-[indene-1,2'-indolin] scaffolds bearing an all-carbon C3-quaternary center proceeding via a Rh (III) catalytic cycle. The protocol...
We have developed a new, simple methodology that allows the formation of well-defined highly enantioselective active species containing two different monodentate ligands coordinated at the same time to the metal center (ML1L2).