A new concept allowed the regioselective synthesis of hydantoinyl-ribose, a contracted uridine. The physiochemical properties of the latter have been determined.
A new and highly efficient ring-closing metathesis-based strategy was developed for the synthesis of the cyclic urea 1,3-diazepinone, presenting significant improvement upon previous methods.
Silane promoted glycosylation and its applications for preparation of active pharmaceutical ingredients.
A solvent-free, Lewis acid-catalyzed synthesis of 2-deoxy-2-bromo-hexopyrano-β-nucleosides achieves high stereo- and regioselectivity showcases broad substrate scope with pyrimidine and purine bases.
We reported the synthesis and anti-RSV or anti-IFV activities of NHC derivatives and 4′-fluorouridine prodrugs, which were evaluated for their chemical stability and PK properties. Tri-isobutyrate ester 1a has potential to be as an antiviral agent.