[Ch][Triz] IL was effective for catalyzing the synthesis of quinazoline-2,4(1H,3H)-diones via cyclization of CO2 and 2-aminobenzonitriles under mild conditions (0.1 MPa, 30–50 °C), and a series of products were obtained in high yields.
K2S-mediated one-pot synthesis of quinazolinones or dihydroquinazolinones from o-aminobenzamides (or o-aminobenzonitriles) and calcium carbide offers a cost-effective and sustainable alternative.
An efficient approach for the synthesis of highly diverse tetrahydroquinazoline scaffolds from 2-aminobenzonitriles and alkylidene malonates via 1,4-conjugate addition followed by an unprecedented rearrangement reaction in excellent yields is reported.
This review summarizes the recent progress in the field of the synthesis of N-heterocyclic skeletons through three types of conversion reactions of nitriles using transition metal-catalyzed and metal-free promoted strategies.
A cost-effective one-pot KOtBu-mediated method synthesizes quinazolinobenzoxazepines from 2-aminobenzonitriles and 2-(2-bromoethoxy)benzaldehydes with broad substrate scope and good functional group tolerance.