Membrane assisted solvent extraction (MASE) is an appealing environmental-friendly pre-treatment for isolating trace targets. MASE applicability in the forensic laboratory is demonstrated by assessing synthetic cannabinoid receptor agonists in urine.
A method for the sensitive HPLC-MS detection of various synthetic cannabinoids in human blood has been developed based on magnetic ferric oxide and polydopamine MIP nanocomposites.
Alzheimer's disease (AD) is a complex neurodegenerative disease with biological signatures of amyloid beta (Aβ) aggregated plaques and increased levels of bio-metals like copper (Cu), zinc (Zn), and iron (Fe).
Two lead compounds, 5a and 5l, designed on an imidazo[1,2-a]quinoxaline template, emerged as potent EGFR inhibitors and anti-lung cancer agents.
An atom-economical and operationally simple method for synthesising γ-keto- and γ-hydroxy-sulfones has been developed using sulfinamides as the sulfur source. The mild reaction conditions used are compatible with a variety of Michael acceptors.