Anna P. Valaka, Hampus Nyström, Liliana Håversen, Carlos Benitez-Martin, Clara Schäfer, Woo Suk Jang, Alessandro Camponeschi, Joakim Andréasson, Jan Borén and Morten Grøtli
RSC Chem. Biol., 2025,6, 618-629
Abstract
Development of a novel fluorescent probe for endogenous BTK imaging using evobrutinib as a scaffold. Evo-2 enabled real-time visualisation of BTK dynamics in living cells while preserving its enzymatic activity.
Yonghui Sun, Zimo Yang, Zhimin Zhang, Zhen Li, Liubin Guo, Hao Pan, Xin Luo, Dongzhou Liu and Yu Rao
RSC Med. Chem., 2023,14, 1562-1566
Abstract
Development of a novel PROTAC molecule targeting BTK protein with better PK properties in vivo.
Sudhakar Tangallapalli, Rambabu Gundla, Kalyani Paidikondala, Soňa Gurská, Naveen Kumar Rampeesa, Sreenivasa Reddy Anugu, Petr Džubák, Marián Hajdúch, Viswanath Das and Naresh Kumar Katari
RSC Adv., 2025,15, 47565-47586
Abstract
This study reports the design, synthesis, and biological evaluation of a novel series of 3-oxo-2,3-dihydropyridazine derivatives for selective inhibition of ITK, with potential application in T-cell leukemia treatment.
Shubhanshu Ranjan Tiwari, Shanmukha Prasad Gopi, Divya Jyothi Kallem, Deepika Chaturvedi, Raja Sekhar Voguri, Srividya Ramakrishnan, Archan Dey and Sharmistha Pal
CrystEngComm, 2023,25, 601-613
Abstract
Insights into the structural features and thermodynamic parameters of a novel ibrutinib–palmitic acid cocrystal based on its crystallographic, thermal, and spectroscopic analysis.
Sijun Pan, Aixiang Ding, Yisi Li, Yaxin Sun, Yueqin Zhan, Zhenkun Ye, Ning Song, Bo Peng, Lin Li, Wei Huang and Huilin Shao
Chem. Soc. Rev., 2023,52, 5706-5743
Abstract
Integrated development of designer chemical tools and complementary analytical technologies empowers new scientific and clinical opportunities.