Development of a novel fluorescent probe for endogenous BTK imaging using evobrutinib as a scaffold. Evo-2 enabled real-time visualisation of BTK dynamics in living cells while preserving its enzymatic activity.
Development of a novel PROTAC molecule targeting BTK protein with better PK properties in vivo.
This study reports the design, synthesis, and biological evaluation of a novel series of 3-oxo-2,3-dihydropyridazine derivatives for selective inhibition of ITK, with potential application in T-cell leukemia treatment.
We propose a computational framework to explore pocket-aware inhibitors targeting the J pocket of BTK kinase by integrating generative deep learning, molecular docking, and molecular dynamics simulations.
Integrated development of designer chemical tools and complementary analytical technologies empowers new scientific and clinical opportunities.