Isaac S. Schomberg-Sanchez, William C. Robinson, Makayla E. Sanderson, Martín A. Mosquera and Christopher M. Lemon
Chem. Sci., 2026,17, 602-616
Abstract
We have developed hangman dipyrrin complexes with secondary sphere residues that perform proton transfer and bind small molecules. Atropisomerism confers rigidity, mimicking the stable positioning of amino acid side chains in protein active sites.
Zhou Xu, Zhongyuan Wang, Xiaona Shi, Rui Ding, Li Han, Xueping Yang, Hongmei Zhang and Adrian D. Hobson
RSC Med. Chem., 2024,15, 2357-2371
From themed collection:
Highlights from Industry
Abstract
A torsion angle scan of a virtual library predicts compounds that will afford stable atropisomers identified as potent non-steroidal glucocorticoid receptor modulators.
Olga Yunyaeva, Duane Hean and Michael O. Wolf
Org. Biomol. Chem., 2023,21, 9623-9629
Abstract
Alkylation of dinapthyl pyridines results in highly emissive atropisomers with restricted rotation.
Jack M. Wootton, Natalie J. Roper, Catrin E. Morris, Victoria E. Maguire, Lee C. Duff, Paul G. Waddell, Adrian C. Whitwood, Richard J. Gammons, Afjal H. Miah, Jason M. Lynam, Roly J. Armstrong and William P. Unsworth
Chem. Sci., 2025,16, 3938-3945
From themed collection:
15th anniversary: Chemical Science community collection
Abstract
A stereoselective strategy to make C–N atropisomeric amides based on intramolecular acyl transfer via a tethered Lewis basic pyridine or tertiary amine group is reported.
Weiwei Luo, Yu Zhang, Meijun Ming and Lin Zhang
Org. Chem. Front., 2024,11, 6819-6849
From themed collection:
2024 Organic Chemistry Frontiers HOT articles
Abstract
This review highlights recent advances in the atroposelective preparation of axially chiral azole derivatives, emphasizing mechanistic insights and synthetic applications in the development of this class of five-membered heterocyclic frameworks.