DNA gyrase and topoisomerase IV are validated targets for developing dual-targeting antibacterial agents.
An efficient synthesis of 2H-chromene-fused thiazolo-triazoles via a multicomponent cascade C–N/C–S bond-forming strategy is reported. Biological evaluation and computational studies identify potent dual anticancer and antibacterial candidates.
A multi-target and molecular hybridization drug design approach was used in the design and synthesis of novel 6-acetylnaphthalene-2-sulfonamide derivatives (5a–5j) for anticancer and antimicrobial evaluation.
A series of diverse 2′-oxo-6b,7,8,9-tetrahydro-6H-spiro[chromeno[3,4-a]pyrrolizine-11,3′-indoline]-6a(11aH)-carbaldehyde derivatives are synthesized and antibacterial evaluation is done along with computational studies.
Aqueous 1,3-dipolar cycloaddition of indenoquinoxaline nitrones with 2H-chromenes affords dispiro chromeno-indenoquinoxaline hybrids with anticancer, antibacterial, and selective Fe2+/Pd2+ fluorescence sensing properties.