DNA gyrase and topoisomerase IV are validated targets for developing dual-targeting antibacterial agents.
A multi-target and molecular hybridization drug design approach was used in the design and synthesis of novel 6-acetylnaphthalene-2-sulfonamide derivatives (5a–5j) for anticancer and antimicrobial evaluation.
A series of diverse 2′-oxo-6b,7,8,9-tetrahydro-6H-spiro[chromeno[3,4-a]pyrrolizine-11,3′-indoline]-6a(11aH)-carbaldehyde derivatives are synthesized and antibacterial evaluation is done along with computational studies.
A thia-Michael addition reaction was developed for the synthesis of heteroaromatic thiol-based 2H-chromenes and the antibacterial activity was studied against two pathogenic bacterial strains, E. coli, and S. aureus.
A series of 3-(2,2-dialkyl-2H-chromen-4-yl)-2-phenylimidazo[1,2-a]pyridine derivatives were synthesis. Molecular docking studies and antibacterial evaluation validates as potent druggable antibacterial agents in future.