De-Gao Wang, Jia-Qi Hu, Chao-Yi Wang, Teng Liu, Yue-Zhong Li and Changsheng Wu
Nat. Prod. Rep., 2025,42, 1459-1488
Abstract
NMR-based metabolomics—whether applied independently or harmonized with genomics—offers a potent lens into microbes' chemical repertoire. The judicious integration of artificial intelligence (AI) further amplifies the potential of this advanced methodology, ushering in new frontiers for microbial natural products discovery.
Mohammad Awashra and Piotr Młynarz
Nanoscale Adv., 2023,5, 2674-2723
From themed collection:
Recent Review Articles
Abstract
The interaction of nanoparticles (NPs) with cells depends on their physicochemical properties and can lead to cytotoxic events. Metabolomics reveals the molecular mechanisms of this nanotoxicity and avoids the misleading interferences with NPs.
Adriano Rutz, Wout Bittremieux, Robin Schmid, Olivier Cailloux, Justin J. J. van der Hooft and Mehdi A. Beniddir
Nat. Prod. Rep., 2026, Advance Article
From themed collection:
Mass Spectrometry Metabolomics in Natural Products Research
Abstract
This review aims at highlighting how scalability of the mass spectrometry-based discovery pipeline plays a pivotal role in finding novel bioactives in natural extracts libraries.
Jianye Zhang, Mingna Sun, Abeer H. Elmaidomy, Khayrya A. Youssif, Adham M. M. Zaki, Hossam Hassan Kamal, Ahmed M. Sayed and Usama Ramadan Abdelmohsen
Food Funct., 2023,14, 9050-9082
From themed collection:
Food & Function Review Articles 2023
Abstract
The study of all chemical processes involving metabolites is known as metabolomics.
Kevin Mildau, Henry Ehlers, Mara Meisenburg, Elena Del Pup, Robert A. Koetsier, Laura Rosina Torres Ortega, Niek F. de Jonge, Kumar Saurabh Singh, Dora Ferreira, Kgalaletso Othibeng, Fidele Tugizimana, Florian Huber and Justin J. J. van der Hooft
Nat. Prod. Rep., 2025,42, 982-1019
From themed collection:
Mass Spectrometry Metabolomics in Natural Products Research
Abstract
Untargeted metabolomics faces researchers with complex processing, analysis, and interpretation tasks. Here, we review computational tools from the perspective of information visualization and underpin its critical role and importance to the field.