Simple phenylpropanoids: recent advances in biological activities, biosynthetic pathways, and microbial production

Zhanpin Zhu, Ruibing Chen and Lei Zhang

Nat. Prod. Rep., 2024, 41, 6
DOI: 10.1039/D3NP00012E

Carbon Monoxide-Releasing Activity of Plant Flavonoids

Lucie Muchová, Mária Šranková, Sriram Balasubramani, Panshul Mehta, Dafni Vlachopoulou, Akshat Kapoor, Andrea Ramundo, Yann Anton Jézéquel, Igor Bożek, Martina Hurtová, Petr Klán, Vladimír Křen and Libor Vítek

J. Agric. Food Chem., 2025, 73, 1308
DOI: 10.1021/acs.jafc.4c09069

Enhanced diastereomeric mixture analysis through integration of quantum chemical calculations with spatio-conformational information obtained from ultraselective NMR techniques

Miyeon Bang and Jin Wook Cha

Appl Biol Chem, 2025, 68
DOI: 10.1186/s13765-025-01030-9

7-O-tyrosyl Silybin Derivatives as a Novel Set of Anti-Prostate Cancer Compounds

Valeria Romanucci, Rita Pagano, Kushal Kandhari, Armando Zarrelli, Maria Petrone, Chapla Agarwal, Rajesh Agarwal and Giovanni Di Fabio

Antioxidants, 2024, 13, 418
DOI: 10.3390/antiox13040418

Nutraceuticals silybin B, resveratrol, and epigallocatechin-3 gallate-bind to cardiac muscle troponin to restore the loss of lusitropy caused by cardiomyopathy mutations in vitro, in vivo, and in silico

Zeyu Yang, Alice M. Sheehan, Andrew E. Messer, Sharmane Tsui, Alexander Sparrow, Charles Redwood, Vladimir Kren, Ian R. Gould and Steven B. Marston

Front. Physiol., 2024, 15
DOI: 10.3389/fphys.2024.1489439

Silymarin decreases liver stiffness associated with gut microbiota in patients with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, placebo-controlled trial

Yufeng Jin, Xin Wang, Ke Chen, Yu Chen, Lixin Zhou, Yupeng Zeng, Yuqing Zhou, Zhijun Pan, Di Wang, Zhongxia Li, Yongqian Liang, Wenhua Ling and Dan Li

Lipids Health Dis, 2024, 23
DOI: 10.1186/s12944-024-02220-y

Bio-Actives from Natural Products with Potential Cardioprotective Properties: Isolation, Identification, and Pharmacological Actions of Apigenin, Quercetin, and Silibinin

Ekaterina-Michaela Tomou, Paraskevi Papakyriakopoulou, Helen Skaltsa, Georgia Valsami and Nikolaos P. E. Kadoglou

Molecules, 2023, 28, 2387
DOI: 10.3390/molecules28052387

Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp

Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan and Jingquan Dong

Environmental Toxicology and Pharmacology, 2024, 106, 104351
DOI: 10.1016/j.etap.2023.104351

Polyphenols of the Inuleae-Inulinae and Their Biological Activities: A Review

Janusz Malarz, Klaudia Michalska and Anna Stojakowska

Molecules, 2024, 29, 2014
DOI: 10.3390/molecules29092014

The novel hepatoprotective mechanisms of silibinin-phospholipid complex against d-GalN/LPS-induced acute liver injury

Shan Tang, Xiaodan Zhang, Zhongping Duan, Manman Xu, Ming Kong, Sujun Zheng, Li Bai and Yu Chen

International Immunopharmacology, 2023, 116, 109808
DOI: 10.1016/j.intimp.2023.109808

Inhibitory effect of flavonoids on multidrug and toxin extrusion protein 1 function: Implications for food/herb–drug interaction and drug‐induced kidney injury

Xiaoyan Duan, Wanting Bai, Jiahuan Hu, Jinjin Wu, Huixin Tan, Fenghe Wang, Xuli Lang, Baolian Wang and Jinping Hu

J of Applied Toxicology, 2024, 44, 1388
DOI: 10.1002/jat.4628

Novel insights into acetylation kinetics in a continuous Flow milli-reactor for chemo-enzymatic separation of silybin A/B

Michele Emanuele Fortunato, Rita Pagano, Valeria Romanucci, Chiara Licenziato, Armando Zarrelli, Martino Di Serio, Giovanni Di Fabio and Vincenzo Russo

J Flow Chem, 2024, 14, 585
DOI: 10.1007/s41981-024-00329-w

Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity

Martina Hurtová, Kristýna Káňová, Simona Dobiasová, Kateřina Holasová, Denisa Čáková, Lan Hoang, David Biedermann, Marek Kuzma, Josef Cvačka, Vladimír Křen, Jitka Viktorová and Kateřina Valentová

IJMS, 2022, 23, 15121
DOI: 10.3390/ijms232315121

In vitro effects of undifferentiated callus extracts from Plantago major L, Rhodiola rosea L and Silybum marianum L in normal and malignant human skin cells

Anette Gjörloff Wingren, Riyam Ziyad Faik, Anna Holefors, Edina Filecovic and Anna Gustafsson

Heliyon, 2023, 9, e16480
DOI: 10.1016/j.heliyon.2023.e16480

Silymarin and Inflammation: Food for Thoughts

Peter F. Surai, Anton Surai and Katie Earle-Payne

Antioxidants, 2024, 13, 98
DOI: 10.3390/antiox13010098

Progress in approved drugs from natural product resources

Zhongwen LUO, Fucheng YIN, Xiaobing WANG and Lingyi KONG

Chinese Journal of Natural Medicines, 2024, 22, 195
DOI: 10.1016/S1875-5364(24)60582-0

Spectroscopic investigation and structural simulation in human serum albumin with hydroxychloroquine/Silybum marianum and a possible potential COVID‐19 drug candidate

Maryam S. H. Tekyeh, Seyed M. M. Shushtarian, Alireza I. Bakhsh, Saeed H. Tackallou and Hossein Lanjanian

Archiv der Pharmazie, 2024, 357
DOI: 10.1002/ardp.202300751

The synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats

Nahed Abdel-Aziz, Azza EL-Bahkery and Ehab A. Ibrahim

Mol Biol Rep, 2025, 52
DOI: 10.1007/s11033-025-10255-2

Dual-targeting galactose-functionalized hyaluronic acid modified lipid nanoparticles delivering silybin for alleviating alcoholic liver injury

Xin Yu Liu, He Ying Mao, Shuai Hong, Cheng-Hua Jin, Hu-Lin Jiang and Ming Guan Piao

International Journal of Pharmaceutics, 2024, 666, 124662
DOI: 10.1016/j.ijpharm.2024.124662

Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review

Hafiza Madiha Jaffar, Fahad Al‐Asmari, Faima Atta Khan, Muhammad Abdul Rahim and Eliasse Zongo

Food Science & Nutrition, 2024, 12, 3097
DOI: 10.1002/fsn3.4010

Topical treatment of tea saponin stabilized silybin nanocrystal gel reduced oxidative stress in UV-induced skin damage

Huan Gu, Xing Liu, Ping Chen, Mingyi Shi, Liping chen and Xiaofang Li

Biochemical and Biophysical Research Communications, 2023, 660, 82
DOI: 10.1016/j.bbrc.2023.04.016

Characterization of metabolites from milk thistle flavonolignans generated by human fecal microbiota

Eva-Maria Pferschy-Wenzig, Olaf Kunert, Timo Thumann, Christine Moissl-Eichinger and Rudolf Bauer

Phytochemistry, 2023, 215, 113834
DOI: 10.1016/j.phytochem.2023.113834

Agricultural phenotype and silymarin content variations of cultivated milk thistle in Korea

Jeehyoung Shim, Hyejin Cho, Jung Sook Sung, Eunae Yoo, Joong Hyoun Chin and Sanghyun Lee

Hortic. Environ. Biotechnol., 2024, 65, 891
DOI: 10.1007/s13580-024-00618-2

Mutual Interactions of Silymarin and Colon Microbiota in Healthy Young and Healthy Elder Subjects

Katerina Tomisova, Veronika Jarosova, Petr Marsik, Anna Mascellani Bergo, Ondrej Cinek, Lucie Hlinakova, Pavel Kloucek, Vaclav Janousek, Kateřina Valentová and Jaroslav Havlik

Molecular Nutrition Food Res, 2024, 68
DOI: 10.1002/mnfr.202400500

Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review

Yan Wang, Wenmin Yang, Yuan Yang, Xingning Liu, Lanfen Peng, Qi Huang, Kongli Fan, Rui Hu, Jinyu Yi, Xin Zhong, Jing Li, Jialing Sun and Xiaozhou Zhou

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1516204

Combined Silymarin and Cotrimoxazole Therapy Attenuates Pulmonary Fibrosis in Experimental Paracoccidioidomycosis

Victor Quinholes Resende, Karoline Hagata Reis-Goes, Angela Carolina Finato, Débora de Fátima Almeida-Donanzam, Amanda Ribeiro dos Santos, Jonatas Perico, Barbara Casella Amorim and James Venturini

JoF, 2022, 8, 1010
DOI: 10.3390/jof8101010

5,7-Dimethoxychroman-3-yl 4-methoxybenzoate Has a Unique Effect upon the Modulation of Mutant Cardiac Muscle Thin Filament Function and Dynamics due to Phosphorylation of Troponin I

Zeyu Yang, Alice M. Sheehan, Mary Papadaki, Andrew E. Messer, Brian S. J. Blagg, Ian R. Gould and Steven B. Marston

ACS Pharmacol. Transl. Sci., 2025, 8, 1251
DOI: 10.1021/acsptsci.5c00156

Silibinin Induces Both Apoptosis and Necroptosis with Potential Anti-tumor Efficacy in Lung Cancer

Guoqing Zhang, Li Wang, Limei Zhao, Fang Yang, Chunhua Lu, Jianhua Yan, Song Zhang, Haiping Wang and Yixiang Li

ACAMC, 2024, 24, 1327
DOI: 10.2174/0118715206295371240724092314

Current status and prospects of phytochemistry, pharmacological activity and medicinal and food applications of the genus Illicium Linn

Sijie Yang, Jingcheng Li, Yi Luo, Jincai Lu and Chongning Lv

Food Research International, 2025, 217, 116816
DOI: 10.1016/j.foodres.2025.116816

Silibinin accelerates diabetic wound healing through PI3K/Akt-mediated immunomodulation-angiogenesis crosstalk

Hanghang Zhou, Jianxiong Qiao, Haixia Su, Jingjing Guo, Zeliang He, Xiaoting Ma, Yonghong Qin and Xuanfen Zhang

Biochemical and Biophysical Research Communications, 2025, 784, 152649
DOI: 10.1016/j.bbrc.2025.152649

Core Structure–Activity Relationship Studies of 5,7,20-O-Trimethylsilybins in Prostate Cancer Cell Models

Sitong Wu, Guanglin Chen, Eva Y. Chen, Leyla S. Farshidpour, Qiang Zhang, Guangdi Wang and Qiao-Hong Chen

Pharmaceuticals, 2023, 16, 531
DOI: 10.3390/ph16040531

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová and Miklós Poór

J Sci Food Agric, 2025, 105, 2765
DOI: 10.1002/jsfa.14045

Silibinin alleviates DNA damage, mitochondrial dysfunction, and apoptosis caused by oxidative stress in human retinal pigment epithelial cells

Yung Hyun Choi

Mol. Cell. Toxicol., 2024, 20, 709
DOI: 10.1007/s13273-023-00412-8

Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells

Sara Verdura, José Antonio Encinar, Salvador Fernández-Arroyo, Jorge Joven, Elisabet Cuyàs, Joaquim Bosch-Barrera and Javier A. Menendez

IJMS, 2022, 23, 9986
DOI: 10.3390/ijms23179986

Photoprotective Effects of Phytochemicals on Blue Light-Induced Retinal Damage: Current Evidence and Future Perspectives

Wan-Ju Yeh, Cin Yan and Chi-Hao Wu

Nutrients, 2025, 17, 331
DOI: 10.3390/nu17020331

Gut microbiota: A potential enhancing factor for the therapeutic efficacy of bioactive compounds in herbal medicines

Yu Chen, Ziqin Lei, Deying Gu, Huiling Zhao, Rong Yu, Qin He, Min Xu and Huan Du

Fitoterapia, 2025, 183, 106570
DOI: 10.1016/j.fitote.2025.106570

Ros-responsive dextran-phenylboronic acid-silibinin nanoparticles for targeting delivery of BAPTA-AM to effectively eliminate calcium overload-mediated inflammatory cascades and mitochondrial apoptosis: Alleviating acute liver injury

Yanan Wang, Huichao Wei, Keyang Li, Liru Liu, Yingfei Zhu, Xinyuan Wang, Jiahui Yan, Liangmin Yu, Xuefeng Yan and Zhiyu He

Chemical Engineering Journal, 2024, 480, 148283
DOI: 10.1016/j.cej.2023.148283

Prunella vulgaris polyphenols alleviate liver injury-uveitis comorbidity by regulating acylcarnitine via the S100A9-PP2A-AMPK pathway

Jingchen Xie, Suhui Xiong, Jiahui Yu, Xinyi Ma, Feng Xiang, Yang Chen, Bohou Xia, Yamei Li, Zhimin Zhang, Duanfang Liao and Limei Lin

Phytomedicine, 2025, 141, 156675
DOI: 10.1016/j.phymed.2025.156675

Silybin attenuates microglia-mediated neuroinflammation via inhibition of STING in experimental subarachnoid hemorrhage

Yue Cui, Si-Min Zhi, Peng-Fei Ding, Ting Zhu, Xiang-Xin Chen, Xun-Zhi Liu, Bin Sheng, Xiao-Jian Li, Jie Wang, Jia-Tong Zhang, Meng-Xiao Xu, Yong-Xiao Jiang, Chun-Hua Hang and Wei Li

International Immunopharmacology, 2025, 151, 114305
DOI: 10.1016/j.intimp.2025.114305

Especies vegetales para las alteraciones hepatobiliares: cardo mariano

Marta Sánchez and M. Pilar Gómez-Serranillos Cuadrado

Panorama Actual Med., 2025, 139
DOI: 10.63105/PAM16

Targeted discovery of oxygen-bridged sesquiterpenes from Cinnamomum migao by MS/MS-based molecular networking and their neuroprotective activities

Lang Zhou, Xiong Pan, Fa-ju Chen, Mei Peng, Yu Wang, Ming Gao, Li-shou Yang, Liang-qun Li, Juan Yang, Xiao-sheng Yang and Qi-ji Li

Phytochemistry, 2025, 236, 114519
DOI: 10.1016/j.phytochem.2025.114519

Nutritional Dynamics of Iranian Pasture Flora: Implications for Animal Health and Productivity

Mohsen Kazemi and Ali Ariapour

Grass and Forage Science, 2025, 80
DOI: 10.1111/gfs.12718

Silybin modulates hepato-intestinal redox/immune homeostasis and lipid turnover via AMPK/Nrf2/NF-κB crosstalk in juvenile largemouth bass fed high-energy diets

Kaige Song, Lianfeng Shen, Xiaohui Li, Hanxu Kang, Longlong Shi, Qiao Liu, Xue Du, Rabia Tahir, Song Yang and Liulan Zhao

Fish & Shellfish Immunology, 2025, 166, 110622
DOI: 10.1016/j.fsi.2025.110622

Development of Technology of Phytosubstantiation of Silybum marianum L. Fruits as a Component of Complex Therapy of Liver Diseases

B. A. Peres, A. P. Procyuk, A. B. Zelencova, I. E. Kauhova, M. V. Aroyan and E. K. Novikova

Razrabotka i registraciâ lekarstvennyh sredstv, 2023
DOI: 10.33380/2305-2066-2023-12-4-1582