The role of charge regulation on casein–chitosan complexation at low pH

Rafael Leonardo Cruz Gomes da Silva, Nina S. Wang, Fernando L. Barroso da Silva and Denise F. S. Petri

Soft Matter, 2026, 22, 926
DOI: 10.1039/D5SM01042J

Environment-responsive polydopamine nanoparticle cross-linked phenylboronic-grafted hyaluronic acid with enzyme-like properties for tumor synergistic therapy

Qing Ji, Mengya Zhu, Xinyuan Li, Wenxiao Cheng and Zhengzou Fang

Nanoscale, 2025, 17, 15988
DOI: 10.1039/D5NR00964B

Insights on the therapeutic potential of fibrinolytic enzymes, emphasis on Nattokinase and its enhanced production using advanced technologies: a critical review

Anju Kanjirakandi Ashokan and V. Mohanasrinivasan

Discov Appl Sci, 2025, 7
DOI: 10.1007/s42452-025-07102-1

Improvement of the fibrinolytic activity, acid resistance and thermostability of nattokinase by surface charge engineering

Yuan Li, Xiyu Tang, Liangqi Chen, Aixia Ma, Wenhui Zhu, Weidong Huang and Jinyao Li

International Journal of Biological Macromolecules, 2023, 253, 127373
DOI: 10.1016/j.ijbiomac.2023.127373

Screening of a Bacillus subtilis strain producing both nattokinase and milk-clotting enzyme and its application in fermented milk with thrombolytic activity

Xuan Zhang, Yanjun Tong, Jing Wang, Xiaomei Lyu and Ruijin Yang

Journal of Dairy Science, 2021, 104, 9437
DOI: 10.3168/jds.2020-19756

Biotechnology, Bioengineering and Applications of Bacillus Nattokinase

Li Yuan, Chen Liangqi, Tang Xiyu and Li Jinyao

Biomolecules, 2022, 12, 980
DOI: 10.3390/biom12070980

Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats

Mustafa M. M. Elbakry, Somaya Z. Mansour, Hamed Helal and Esraa S. A. Ahmed

Environ Sci Pollut Res, 2022, 29, 75086
DOI: 10.1007/s11356-022-21126-9

Mucoadhesive carriers for oral drug delivery

Raj Kumar, Tamanna Islam and Md Nurunnabi

Journal of Controlled Release, 2022, 351, 504
DOI: 10.1016/j.jconrel.2022.09.024

Wet-Spun Chitosan–Sodium Caseinate Fibers for Biomedicine: From Spinning Process to Physical Properties

Hazel Peniche, Ivy Ann Razonado, Pierre Alcouffe, Guillaume Sudre, Carlos Peniche, Anayancy Osorio-Madrazo and Laurent David

IJMS, 2024, 25, 1768
DOI: 10.3390/ijms25031768

Application of bentonite-chitosan nanocomposites for the adsorptive removal of iron and natural organic matter in peat water

Edwin Permana, M. Naswir, Dhian Eka Wijaya, Ali Nurdin Hidayat, Dimas Setya Nurjamil and Andrian Setyarestu Prayogi

J. Degrade. Min. Land Manage., 2025, 12, 8107
DOI: 10.15243/jdmlm.2025.124.8107

Layer-by-layer self-assembly embedding of nattokinase in chitosan/γ-polyglutamic acid: Preparation, fibrinolytic activity, stability, and in vitro digestion study

Zhihan Liu, Yan He, Hua Zhang and Xia Ma

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 199, 114281
DOI: 10.1016/j.ejpb.2024.114281

Research progress on the utilisation of embedding technology and suitable delivery systems for improving the bioavailability of nattokinase: A review

Xueqin Zhou, Liangzhong Liu and Xurui Zeng

Food Structure, 2021, 30, 100219
DOI: 10.1016/j.foostr.2021.100219

Research Progress on Nattokinase and Its Bioengineering

飞龙林

HJBM, 2023, 13, 240
DOI: 10.12677/HJBM.2023.132027

Production, purification, and functional properties of microbial fibrinolytic enzymes produced by microorganism obtained from soy-based fermented foods: developments and challenges

Mingjing Yao, Yang Yang, Jing Fan, Chunmin Ma, Xiaofei Liu, Yan Wang, Bing Wang, Zhihui Sun, David Julian McClements, Jiaxiang Zhang, Liping Liu, Guanghua Xia, Na Zhang and Quancai Sun

Critical Reviews in Food Science and Nutrition, 2024, 64, 3725
DOI: 10.1080/10408398.2022.2134980

Bioinspired synthesis of protein/polysaccharide-decorated folate as a nanocarrier of curcumin to potentiate cancer therapy

Nihal S. Elbialy, Samia F. Aboushoushah and Noha Mohamed

International Journal of Pharmaceutics, 2022, 613, 121420
DOI: 10.1016/j.ijpharm.2021.121420

Characterization of a Nattokinase from the Newly Isolated Bile Salt-Resistant Bacillus mojavensis LY-06

Yuan Li, Xiyu Tang, Liangqi Chen, Xinran Xu and Jinyao Li

Foods, 2022, 11, 2403
DOI: 10.3390/foods11162403

The composition, microstructure, interaction with polysaccharides of casein micelles and their potential application as drug delivery-a review

Qian Wang, Yaoqin Liu, Ying Ma, Yu Lu, Linjuan Huang and Zhongfu Wang

Food Bioscience, 2025, 65, 106068
DOI: 10.1016/j.fbio.2025.106068

Process development of nattokinase microcapsules based on a novel sodium alginate-gelatin-chitosan composite material

Junying Sun, Feifei Mao and Tongjun Liu

Preparative Biochemistry & Biotechnology, 2026, 56, 261
DOI: 10.1080/10826068.2025.2528396

Casein‐based conjugates and graft copolymers. Synthesis, properties, and applications

Laurianne Viora, Teddy Tichané, Benjamin Nottelet, Julia Mouton, Xavier Garric, Hélène Van Den Berghe and Jean Coudane

Comp Rev Food Sci Food Safe, 2024, 23
DOI: 10.1111/1541-4337.13306

Preparation and property studies of enteric-soluble oral nattokinase microcapsules with halloysite nanotubes

Wen-song Hu, Meng-jie Zhou, Liu-xiu Hu, Kai Huang, Shi-guang Zhao, Sen-he Qian, Zhou Wang, Xi-lin Huang, Jun-Bao Huang, Jian Wang, Xue-yan Liang, Wei Luo, Zheng-lian Xue and Yan Liu

International Journal of Polymeric Materials and Polymeric Biomaterials, 2024, 73, 688
DOI: 10.1080/00914037.2023.2201948

Research progress on the fibrinolytic enzymes produced from traditional fermented foods

Panpan Wang, Cuiying Peng, Xiaomei Xie, Xiongwei Deng and Meizhi Weng

Food Science & Nutrition, 2023, 11, 5675
DOI: 10.1002/fsn3.3601

Preserving the activity of attenuating atherosclerosis of nattokinase in gastrointestinal system by NK/SA/CS microcapsules

Minghao Xie, Meilian Yang, Zhenyu Wang, Shuzhen Cheng and Ming Du

Food Bioscience, 2024, 59, 103949
DOI: 10.1016/j.fbio.2024.103949

“Three-birds-one-stone” environment responsive delivery system with tumor microenvironment remodeling to enhance solid tumor therapy

Chunmin Deng, Dong Shen, Mengyi Li, Changsong Zhang and Qingzhen Wang

Cancer Nano, 2026, 17
DOI: 10.1186/s12645-026-00368-z

Preparation, Characterization and Drug Delivery Research of γ-Polyglutamic Acid Nanoparticles: A Review

Zhihan Liu, Yan He and Xia Ma

CDD, 2024, 21, 795
DOI: 10.2174/1567201820666230102140450

Combined Computer-Aided Predictors to Improve the Thermostability of Nattokinase

Yuan Li, Liangqi Chen, Xiyu Tang, Wenhui Zhu, Aixia Ma, Changyu Shi and Jinyao Li

Foods, 2023, 12, 3045
DOI: 10.3390/foods12163045

Decoding nattokinase efficacy: From digestion and absorption to lipid pathway modulation in high-fat diet-induced atherosclerosis

Yongjie Zhou, Zixin Fu, Peipei Dou, Chen Yu, Xianyou Dong, Hui Hong, Yongkang Luo and Yuqing Tan

Food Bioscience, 2025, 66, 106203
DOI: 10.1016/j.fbio.2025.106203

High-Efficiency Fermentation of Nattokinase by Recombinant PSP2 Using Oyster Protein Hydrolysate as a Substrate

Ming Tian, Chen Ning, Siyuan Peng, Deyu Li, Renyi Jin, Yang Zhang, Zhemin Liu, Haijin Mou and Changliang Zhu

Foods, 2023, 12, 1252
DOI: 10.3390/foods12061252

Biodegradable Nanoparticles Prepared from Chitosan and Casein for Delivery of Bioactive Polysaccharides

Chi Lin, Fang-Yu Hsu, Wei-Ting Lin, Chia-Yun Cha, Yi-Cheng Ho and Fwu-Long Mi

Polymers, 2022, 14, 2966
DOI: 10.3390/polym14142966

Recent Advances in Nattokinase-Enriched Fermented Soybean Foods: A Review

Danfeng Li, Lizhen Hou, Miao Hu, Yaxin Gao, Zhiliang Tian, Bei Fan, Shuying Li and Fengzhong Wang

Foods, 2022, 11, 1867
DOI: 10.3390/foods11131867

Nattokinase: Insights into Biological Activity, Therapeutic Applications, and the Influence of Microbial Fermentation

Mudannan Fang, Beichen Yuan, Meng Wang, Junfeng Liu and Zheng Wang

Fermentation, 2023, 9, 950
DOI: 10.3390/fermentation9110950

Biofunctional chitosan–biopolymer composites for biomedical applications

Yabin Guo, Dongling Qiao, Siming Zhao, Peng Liu, Fengwei Xie and Binjia Zhang

Materials Science and Engineering: R: Reports, 2024, 159, 100775
DOI: 10.1016/j.mser.2024.100775

Mechanism of influence of nattokinase terminal sequence on catalytic performance and molecular modification

Yuan Li, Hong Wang, Kongfang Yu, Aixia Ma, Wenhui Zhu, Tongli Li, Yuwei Ma, Ye Ma and Jinyao Li

International Journal of Biological Macromolecules, 2025, 307, 141872
DOI: 10.1016/j.ijbiomac.2025.141872