Design, synthesis and computational approach of vanillyl–imidazolidinyl–sulfamethoxazole derivatives as potent antimicrobial candidates tackling microbial resistance

Preetesh Kumar Panda, Kakarla Pakeeraiah, Suvadeep Mal, Monalisa Mahapatra, Ajit Kumar Bishoyi and Sudhir Kumar Paidesetty

RSC Med. Chem., 2025, 16, 3799
DOI: 10.1039/D5MD00221D

Juglone as a Natural Quorum Sensing Inhibitor against Pseudomonas aeruginosa pqs-Mediated Virulence and Biofilms

Yeping Ma, Wing Suet Tang, Sylvia Yang Liu, Bee Luan Khoo and Song Lin Chua

ACS Pharmacol. Transl. Sci., 2024, 7, 533
DOI: 10.1021/acsptsci.3c00354

Antifungal and Antivirulence Activity of Vanillin and Tannic Acid Against Aspergillus fumigatus and Fusarium solani

Ana L. Ríos-López, Jorge Dávila-Aviña, Gloria M. González and Orlando Flores-Maldonado

Curr Microbiol, 2024, 81
DOI: 10.1007/s00284-024-03678-w

Prevalence of alcohol-tolerant and antibiotic-resistant bacterial pathogens on public hand sanitizer dispensers

Y.W.S. Yeung, Y. Ma, S.Y. Liu, W.H. Pun and S.L. Chua

Journal of Hospital Infection, 2022, 127, 26
DOI: 10.1016/j.jhin.2022.05.017

In vitro evaluation of antileishmanial activity, mode of action and cellular response induced by vanillin synthetic derivatives against Leishmania species able to cause cutaneous and visceral leishmaniasis

Camila S. Freitas, Samira S. Santiago, Daniela P. Lage, Luciana M.R. Antinarelli, Fabrício M. Oliveira, Danniele L. Vale, Vívian T. Martins, Lícia N.D. Magalhaes, Raquel S. Bandeira, Fernanda F. Ramos, Isabela A.G. Pereira, Marcelo M. de Jesus, Fernanda Ludolf, Grasiele S.V. Tavares, Adilson V. Costa, Rafaela S. Ferreira, Elaine S. Coimbra, Róbson R. Teixeira and Eduardo A.F. Coelho

Experimental Parasitology, 2023, 251, 108555
DOI: 10.1016/j.exppara.2023.108555

New synthetic molecules incorporated into polymeric micelles used for treatment against visceral leishmaniasis

Camila S. Freitas, Isabela A.G. Pereira, Daniela P. Lage, Danniele L. Vale, Breno L. Pimenta, Nícia P. Soares, Samira S. Santiago, Vívian T. Martins, Raquel S.B. Câmara, Marcelo M. Jesus, Grasiele S.V. Tavares, Fernanda F. Ramos, Fernanda Ludolf, Lícia N.D. Magalhães, Fabrício M. Oliveira, Mariana C. Duarte, Miguel A. Chávez-Fumagalli, Adilson V. Costa, Bruno M. Roatt, Róbson R. Teixeira and Eduardo A.F. Coelho

Cytokine, 2024, 177, 156543
DOI: 10.1016/j.cyto.2024.156543

Qualitative phytochemical analysis and in vitro investigation of the immunomodulatory properties of honeys produced in Kazakhstan

Pauline McLoone, Dina Tabys, Sofiya Yunussova, Aizhan Zhumbayeva, Susan Verrall, Julie Sungurtas, Ceri Austin, J. William Allwood and Gordon J McDougall

Natural Product Research, 2023, 37, 996
DOI: 10.1080/14786419.2022.2095382

Natural compounds and extracts as novel antimicrobial agents

Paolo Guglielmi, Virginia Pontecorvi and Giulia Rotondi

Expert Opinion on Therapeutic Patents, 2020, 30, 949
DOI: 10.1080/13543776.2020.1853101

Global Trends in and Hotspots of Bacterial Quorum Sensing: A Bibliometric Analysis for the Period 2012–2022

Beiliang Miao, Yu Han, Mengqi Gao, Li Yu, Wenxin Ma, Zeliang Chen, Ning Zhang and Shiwei Liu

Integr Med Nephrol Androl, 2024, 11
DOI: 10.1097/IMNA-D-23-00026

Pseudomonas aeruginosa biofilm: treatment strategies to combat infection

Rashmi Ramesh, N. D. Rekha and Shubha Gopal

Arch Microbiol, 2025, 207
DOI: 10.1007/s00203-025-04346-8

Vanillin and Its Derivatives: A Critical Review of Their Anti-Inflammatory, Anti-Infective, Wound-Healing, Neuroprotective, and Anti-Cancer Health-Promoting Benefits

Magdalini Kafali, Marios Argyrios Finos and Alexandros Tsoupras

Nutraceuticals, 2024, 4, 522
DOI: 10.3390/nutraceuticals4040030

Targeting Quorum Sensing in Pseudomonas aeruginosa Using Marine‐Derived Metabolites—An In Silico Approach

Muntawakilu Padiga Seidu, Alice Adomako, Aaron Boakye, Michael Konney Laryea, Lawrence Sheringham Borquaye and Basavarajaiah S. M.

Journal of Chemistry, 2024, 2024
DOI: 10.1155/joch/2172452

Overlooked interference of antibiotics on quorum sensing inhibitors for membrane biofouling mitigation by affecting AHLs and PQS pathway

Huijie Xu, Yu Yang, Tian Xia, Yuruo Feng, Xinhui Liu, Nigel J.D. Graham, Kwang-Ho Choo, Satoshi Takizawa, How Yong Ng and Li-an Hou

Separation and Purification Technology, 2025, 363, 132116
DOI: 10.1016/j.seppur.2025.132116

Marine-Derived Furanones Targeting Quorum-Sensing Receptors in Pseudomonas aeruginosa: Molecular Insights and Potential Mechanisms of Inhibition

Aaron Boakye, Muntawakilu Padiga Seidu, Alice Adomako, Michael Konney Laryea and Lawrence Sheringham Borquaye

Bioinform Biol Insights, 2024, 18
DOI: 10.1177/11779322241275843

Exploring Marine natural products as potential Quorum sensing inhibitors by targeting the PqsR in Pseudomonas aeruginosa: Virtual screening assisted structural dynamics study

Manikandan Jayaraman, Vijayakumar Gosu, Rajalakshmi Kumar, Jeyakanthan Jeyaraman, Hak-kyo Lee, Donghyun Shin and Yusuf Oloruntoyin Ayipo

PLoS ONE, 2025, 20, e0319352
DOI: 10.1371/journal.pone.0319352

Paeonol Attenuates Quorum-Sensing Regulated Virulence and Biofilm Formation in Pseudomonas aeruginosa

Dan Yang, Suqi Hao, Ling Zhao, Fei Shi, Gang Ye, Yuanfeng Zou, Xu Song, Lixia Li, Zhongqiong Yin, Xiaoli He, Shiling Feng, Helin Chen, Yu Zhang, Yuanze Gao, Yinglun Li and Huaqiao Tang

Front. Microbiol., 2021, 12
DOI: 10.3389/fmicb.2021.692474

Lactic acid bacteria as a tool for biovanillin production: A review

Heba S. Mostafa and Marwa M. Hashem

Biotech & Bioengineering, 2023, 120, 903
DOI: 10.1002/bit.28328

Effect of L-HSL on biofilm and motility of Pseudomonas aeruginosa and its mechanism

Deping Tang, Yanyan Lin, Huihui Yao, Yali Liu, Yanpeng Xi, Mengjiao Li and Aihong Mao

Appl Microbiol Biotechnol, 2024, 108
DOI: 10.1007/s00253-024-13247-7

Tailored multilayer nanoparticles against resistant P. aeruginosa by disrupting the thickened mucus, dense biofilm and hyperinflammation

Mao Xu, Shihui Yu, Pengyu Li, Yili Chen, Yujun Chen, Jieyi Pan, Xin Deng and Haiyan Hu

Journal of Controlled Release, 2025, 378, 588
DOI: 10.1016/j.jconrel.2024.12.040

Evaluation of the antibacterial, antibiofilm, and anti-virulence effects of acetic acid and the related mechanisms on colistin-resistant Pseudomonas aeruginosa

Luozhu Feng, Mengxin Xu, Weiliang Zeng, Xiaodong Zhang, Sipei Wang, Zhuocheng Yao, Tieli Zhou, Shiyi Shi, Jianming Cao and Lijiang Chen

BMC Microbiol, 2022, 22
DOI: 10.1186/s12866-022-02716-6

Antibiotic-Resistant Pseudomonas aeruginosa: Current Challenges and Emerging Alternative Therapies

Minqi Hu and Song Lin Chua

Microorganisms, 2025, 13, 913
DOI: 10.3390/microorganisms13040913

Traditional Chinese Medicine Monomer Bakuchiol Attenuates the Pathogenicity of Pseudomonas aeruginosa via Targeting PqsR

Jing Zeng, Xin Ma, Yu Zheng, Dandan Liu, Wanqing Ning, Wei Xiao, Qian Mao, Zhenqing Bai, Renjun Mao, Juanli Cheng and Jinshui Lin

IJMS, 2024, 26, 243
DOI: 10.3390/ijms26010243

Minimizing bacterial adhesion on membrane: Multiscale characterization of surface modifications

Abigail Burato Rosales, Nadège Durban-Benizio, Xuan Loc Nguyen, Vincent Bouvier, Clémentine Lamo, Irem Demir-Yilmaz, Christel Causserand, Cécile Formosa-Dague and Clémence Coetsier

Journal of Membrane Science, 2023, 684, 121867
DOI: 10.1016/j.memsci.2023.121867

Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibiotic efficacy for controlling Pseudomonas aeruginosa biofilms

Miguel M. Leitão, Tatiana F. Vieira, Sérgio F. Sousa, Fernanda Borges, Manuel Simões and Anabela Borges

Microbial Pathogenesis, 2024, 191, 106663
DOI: 10.1016/j.micpath.2024.106663

Antibacterial effects of vanilla ingredients provide novel treatment options for infections with multidrug-resistant bacteria – A recent literature review

Noah A. Maisch, Stefan Bereswill and Markus M. Heimesaat

EuJMI, 2022, 12, 53
DOI: 10.1556/1886.2022.00015

Repression of resistance mechanisms of Pseudomonas aeruginosa: implications of the combination of antibiotics and phytoconstituents

Susmita Patra, Poulomi Biswas, Sanmoy Karmakar and Kaushik Biswas

Arch Microbiol, 2024, 206
DOI: 10.1007/s00203-024-04012-5

Label-free biosensor of phagocytosis for diagnosing bacterial infections

Junchen Liao, Jifeng Ren, Huang Wei, Raymond H.W. Lam, Song Lin Chua and Bee Luan Khoo

Biosensors and Bioelectronics, 2021, 191, 113412
DOI: 10.1016/j.bios.2021.113412

Periodically disturbing biofilms reduces expression of quorum sensing-regulated virulence factors in Pseudomonas aeruginosa

Laura García-Diéguez, Gabriela Diaz-Tang, Estefania Marin Meneses, Vanessa Cruise, Ivana Barraza, Travis J.A. Craddock and Robert P. Smith

iScience, 2023, 26, 106843
DOI: 10.1016/j.isci.2023.106843

Honey Phytochemicals: Bioactive Agents With Therapeutic Potential for Dermatological Disorders

Pauline McLoone, Toheeb Olalekan Oladejo, Laura Kassym and Gordon J. McDougall

Phytotherapy Research, 2024, 38, 5741
DOI: 10.1002/ptr.8330

Biofilm and Quorum Sensing inhibitors: the road so far

Simone Carradori, Noemi Di Giacomo, Martina Lobefalo, Grazia Luisi, Cristina Campestre and Francesca Sisto

Expert Opinion on Therapeutic Patents, 2020, 30, 917
DOI: 10.1080/13543776.2020.1830059

Inhibition of Virulence Factors and Biofilm Formation by Wogonin Attenuates Pathogenicity of Pseudomonas aeruginosa PAO1 via Targeting pqs Quorum-Sensing System

Shiwei Wang, Yuqi Feng, Xiaofeng Han, Xinyu Cai, Liu Yang, Chaolan Liu and Lixin Shen

IJMS, 2021, 22, 12699
DOI: 10.3390/ijms222312699

Novel Vanillin‐based hybrids inhibit quorum sensing and silences phenotypical expressions in Pseudomonas aeruginosa

Tamanna Dua, Surabhi Mangal, Goel Akshita, Harshdeep, Ankit K. Atri, Purshotam Sharma, Kusum Harjai and Vasundhara Singh

Drug Development Research, 2023, 84, 45
DOI: 10.1002/ddr.22011

Theophylline as a quorum sensing and biofilm inhibitor in Pseudomonas aeruginosa and Chromobacterium violaceum

Aparna Mohan, Pooja P. Rajan, Praveen Kumar, Devi Jayakumar, Minsa Mini, Sneha Asha and Parvathi Vaikkathillam

Int Microbiol, 2024, 27, 1457
DOI: 10.1007/s10123-024-00487-w

Probing the reduction of adhesion forces between biofilms and anti-biofouling filtration membrane surfaces using FluidFM technology

Abigail Burato Rosales, Christel Causserand, Clémence Coetsier and Cécile Formosa-Dague

Colloids and Surfaces B: Biointerfaces, 2024, 234, 113701
DOI: 10.1016/j.colsurfb.2023.113701

A systematic review of synthetic tyrosinase inhibitors and their structure-activity relationship

Zhiyun Peng, Guangcheng Wang, Qiao-Hui Zeng, Yufeng Li, Haiquan Liu, Jing Jing Wang and Yong Zhao

Critical Reviews in Food Science and Nutrition, 2022, 62, 4053
DOI: 10.1080/10408398.2021.1871724

Pyranoanthocyanins Interfering with the Quorum Sensing of Pseudomonas aeruginosa and Staphylococcus aureus

Patrícia Coelho, Joana Oliveira, Iva Fernandes, Paula Araújo, Ana Rita Pereira, Paula Gameiro and Lucinda J. Bessa

IJMS, 2021, 22, 8559
DOI: 10.3390/ijms22168559

Biofilm dispersal induced by mechanical cutting leads to heightened foodborne pathogen dissemination

Tsz-yiu Kwok, Yeping Ma and Song Lin Chua

Food Microbiology, 2022, 102, 103914
DOI: 10.1016/j.fm.2021.103914

Dual-species proteomics and targeted intervention of animal-pathogen interactions

Yang Sylvia Liu, Chengqian Zhang, Bee Luan Khoo, Piliang Hao and Song Lin Chua

Journal of Advanced Research, 2025, 73, 397
DOI: 10.1016/j.jare.2024.08.038

The Building Blocks of Antimicrobial Resistance in Pseudomonas aeruginosa: Implications for Current Resistance-Breaking Therapies

R. Frèdi Langendonk, Daniel R. Neill and Joanne L. Fothergill

Front. Cell. Infect. Microbiol., 2021, 11
DOI: 10.3389/fcimb.2021.665759

Tackling recalcitrant Pseudomonas aeruginosa infections in critical illness via anti-virulence monotherapy

Vijay K. Singh, Marianna Almpani, Damien Maura, Tomoe Kitao, Livia Ferrari, Stefano Fontana, Gabriella Bergamini, Elisa Calcaterra, Chiara Pignaffo, Michele Negri, Thays de Oliveira Pereira, Frances Skinner, Manos Gkikas, Danielle Andreotti, Antonio Felici, Eric Déziel, Francois Lépine and Laurence G. Rahme

Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-32833-9

Anti-QS Strategies Against Pseudomonas aeruginosa Infections

Abdelaziz Touati, Nasir Adam Ibrahim, Lilia Tighilt and Takfarinas Idres

Microorganisms, 2025, 13, 1838
DOI: 10.3390/microorganisms13081838

Oxidative stress induced by Etoposide anti-cancer chemotherapy drives the emergence of tumor-associated bacteria resistance to fluoroquinolones

Shan Wang, Shepherd Yuen Chan, Yanlin Deng, Bee Luan Khoo and Song Lin Chua

Journal of Advanced Research, 2024, 55, 33
DOI: 10.1016/j.jare.2023.02.011

Isovanillin decreases the virulence regulated by the quorum sensing system of Pseudomonas aeruginosa

Junfeng Deng, Yang Yuan, Yi Wu, Fulong Wen, Xiting Yang, Shiyi Gou, Yiwen Chu and Kelei Zhao

Microbial Pathogenesis, 2024, 196, 107010
DOI: 10.1016/j.micpath.2024.107010

The Antimicrobial Potential of Vanillin-Incorporated Irreversible Hydrocolloid Impression Material

Kansichaya Kaewbuadee, Kasinart Paiboonsisijit, Narada Nutchanart, Boonyanit Thaweboon and Sroisiri Thaweboon

KEM, 2023, 942, 77
DOI: 10.4028/p-g78m10

Vanillic acid combats Vibrio alginolyticus by cell membrane damage and biofilm reduction

Huan Liu, Miao Xiao, Jing Zuo, Xiaoxian He, Ping Lu, Yingyu Li, Yanni Zhao and Fei Xia

Journal of Fish Diseases, 2021, 44, 1799
DOI: 10.1111/jfd.13498

Vanillin: a review on the therapeutic prospects of a popular flavouring molecule

Sagar S. Arya, James E. Rookes, David M. Cahill and Sangram K. Lenka

ADV TRADIT MED (ADTM), 2021, 21, 1
DOI: 10.1007/s13596-020-00531-w

Veratryl Alcohol Attenuates the Virulence and Pathogenicity of Pseudomonas aeruginosa Mainly via Targeting las Quorum-Sensing System

Songzhe Fu, Wenxu Song, Xiaofeng Han, Lin Chen and Lixin Shen

Microorganisms, 2024, 12, 985
DOI: 10.3390/microorganisms12050985

Treatment using vanillin-derived synthetic molecules incorporated into polymeric micelles is effective against infection caused by Leishmania amazonensis species

Isabela A.G. Pereira, Camila S. Freitas, Raquel S.B. Câmara, Marcelo M. Jesus, Daniela P. Lage, Grasiele S.V. Tavares, Tauane G. Soyer, Fernanda F. Ramos, Nícia P. Soares, Samira S. Santiago, Vívian T. Martins, Danniele L. Vale, Breno L. Pimenta, Fernanda Ludolf, Fabrício M. Oliveira, Mariana C. Duarte, Miguel A. Chávez-Fumagalli, Adilson V. Costa, Denise U. Gonçalves, Bruno M. Roatt, Róbson R. Teixeira and Eduardo A.F. Coelho

Experimental Parasitology, 2024, 260, 108743
DOI: 10.1016/j.exppara.2024.108743

PqsR-specific quorum sensing inhibitors targeting Pseudomonas aeruginosa : current advances and future directions

Mandsaurwala Aziz, Kafil Ahmed and Vinothkannan Ravichandran

Journal of Chemotherapy, 2025, 1
DOI: 10.1080/1120009X.2025.2510093