Recent advances in functional nanostructured materials for bone-related diseases

Anqi Li, Jing Xie and Jianshu Li

J. Mater. Chem. B, 2019, 7, 509
DOI: 10.1039/C8TB02812E

A novel indomethacin/methotrexate/MMP-9 siRNA in situ hydrogel with dual effects of anti-inflammatory activity and reversal of cartilage disruption for the synergistic treatment of rheumatoid arthritis

Na Yin, Xinyi Tan, Hongbing Liu, Fengming He, Ning Ding, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang and Xing Tang

Nanoscale, 2020, 12, 8546
DOI: 10.1039/D0NR00454E

A biopolymer-based and inflammation-responsive nanodrug for rheumatoid arthritis treatment via inhibiting JAK-STAT and JNK signalling pathways

Ziqian Wang, Chenyue Zhan, Fang Zeng and Shuizhu Wu

Nanoscale, 2020, 12, 23013
DOI: 10.1039/D0NR05551D

Navigating rheumatoid arthritis: insights into ligand-anchored nanoparticle strategies for anti-inflammatory therapy and relief

Shriya Karmarkar, Trinette Fernandes, Zainab Choonia, Sankalp Gharat and Sujata Sawarkar

RSC Pharm., 2025, 2, 19
DOI: 10.1039/D4PM00133H

Multivalent sialic acid materials for biomedical applications

Yusong Cao, Wantong Song and Xuesi Chen

Biomater. Sci., 2023, 11, 2620
DOI: 10.1039/D2BM01595A

Rheumatoid arthritis microenvironment insights into treatment effect of nanomaterials

Yan Zhu, Tianjiao Zhao, Min Liu, Shuya Wang, Saili Liu, Yunrong Yang, Yuqi Yang, Yayun Nan, Qiong Huang and Kelong Ai

Nano Today, 2022, 42, 101358
DOI: 10.1016/j.nantod.2021.101358

Sialic-Acid-Anchored Micelles: A Hierarchical Targeting Device for Enhanced Tumor Tissue Accumulation and Cellular Internalization

Meng-Lu Zhu, Xiao-Ling Xu, Xiao-Juan Wang, Nan-Nan Zhang, Kong-Jun Lu, Jing Qi, Fei-Yang Jin, Di Liu and Yong-Zhong Du

Mol. Pharmaceutics, 2018, 15, 4235
DOI: 10.1021/acs.molpharmaceut.8b00649

Sialic Acid-Functionalized PEG–PLGA Microspheres Loading Mitochondrial-Targeting-Modified Curcumin for Acute Lung Injury Therapy

Feiyang Jin, Di Liu, Hui Yu, Jing Qi, Yuchan You, Xiaoling Xu, Xuqi Kang, Xiaojuan Wang, Kongjun Lu, Xiaoying Ying, Jian You, Yongzhong Du and Jiansong Ji

Mol. Pharmaceutics, 2019, 16, 71
DOI: 10.1021/acs.molpharmaceut.8b00861

Nano-medicine in Treating Reumatoid Arthritics

Jingyuan Wei

HSET, 2022, 2, 186
DOI: 10.54097/hset.v2i.573

Nanomedicine Strategies for Anti‐Inflammatory Treatment of Noninfectious Arthritis

Long Chen, Yuanzheng Wang, Li Sun, Jerry Yan and Hai‐Quan Mao

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202001732

Sialic acid: an attractive biomarker with promising biomedical applications

Aida Doostkam, Leila Malekmakan, Alireza Hosseinpour, Sahar Janfeshan, Jamshid Roozbeh and Fatemeh Masjedi

Asian Biomedicine, 2022, 16, 153
DOI: 10.2478/abm-2022-0020

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Ana Cláudia Lima, Helena Ferreira, Rui L. Reis and Nuno M. Neves

Expert Opinion on Drug Delivery, 2019, 16, 795
DOI: 10.1080/17425247.2019.1635117

Nanomedicines for improved targetability to inflamed synovium for treatment of rheumatoid arthritis: Multi-functionalization as an emerging strategy to optimize therapeutic efficacy

Gang Fang, Qinghuai Zhang, Yuzhou Pang, Hnin Ei Thu and Zahid Hussain

Journal of Controlled Release, 2019, 303, 181
DOI: 10.1016/j.jconrel.2019.04.027

Dynamic nano-assemblies based on two-dimensional inorganic nanoparticles: Construction and preclinical demonstration

Luyao Sun, Jingjing Wang, Li Li and Zhi Ping Xu

Advanced Drug Delivery Reviews, 2022, 180, 114031
DOI: 10.1016/j.addr.2021.114031

Ligand‐Installed Nanocarriers toward Precision Therapy

Peng Mi, Horacio Cabral and Kazunori Kataoka

Advanced Materials, 2020, 32
DOI: 10.1002/adma.201902604

Sialic Acid-Modified NIR-II Fluorophore with Enhanced Brightness and Photoconversion Capability for Targeted Lymphoma Phototheranostics

Fang Nan, Zhongxin Zhou, Qian Bai, Kai Chen, Yu Liu and Shuqi Wu

Anal. Chem., 2025, 97, 2525
DOI: 10.1021/acs.analchem.4c06424

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Irina Negut and Bogdan Bita

Pharmaceutics, 2023, 15, 976
DOI: 10.3390/pharmaceutics15030976

Current Immunotherapy Strategies for Rheumatoid Arthritis: The Immunoengineering and Delivery Systems

Chenyu Zhang, Peixiang Ma, An Qin, Liao Wang, Kerong Dai, Yuanyuan Liu, Jie Zhao and Zuyan Lu

Research, 2023, 6
DOI: 10.34133/research.0220

Harnessing nanochaperone-triggered ferritinophagy for targeted protein degradation and breast cancer therapy

Xiaoling Xu, Qingqing Dong, Yutong Zhao, Jun Yang, Keda Yang, Peifen Fu, Hong Yu, Xiaoyuan Chen, Longguang Tang and Wei Chen

Chemical Engineering Journal, 2025, 525, 169802
DOI: 10.1016/j.cej.2025.169802

Polysialic-Acid-Based Micelles Promote Neural Regeneration in Spinal Cord Injury Therapy

Xiao-Juan Wang, Chen-Han Peng, Shuo Zhang, Xiao-Ling Xu, Gao-Feng Shu, Jing Qi, Ya-Fang Zhu, De-Min Xu, Xu-Qi Kang, Kong-Jun Lu, Fei-Yang Jin, Ri-Sheng Yu, Xiao-Ying Ying, Jian You, Yong-Zhong Du and Jian-Song Ji

Nano Lett., 2019, 19, 829
DOI: 10.1021/acs.nanolett.8b04020

Nanomedicine for the management of rheumatoid arthritis: current status and prospective therapeutic approaches

Neha Gupta, Abdul Rahaman Shaik, Ananda Kumar Chettupalli, Sarad Pawar Naik Bukke and Narayana Goruntla

Discov Med, 2025, 2
DOI: 10.1007/s44337-025-00316-7

Nanomaterial-assisted theranosis of bone diseases

Kai Zheng, Jiaxiang Bai, Huilin Yang, Yaozeng Xu, Guoqing Pan, Huaiyu Wang and Dechun Geng

Bioactive Materials, 2023, 24, 263
DOI: 10.1016/j.bioactmat.2022.12.014

Nanomedicines targeting activated immune cells and effector cells for rheumatoid arthritis treatment

Yasi Deng, Hao Zheng, Bin Li, Feibing Huang, Yun Qiu, Yupei Yang, Wenbing Sheng, Caiyun Peng, Xing Tian, Wei Wang and Huanghe Yu

Journal of Controlled Release, 2024, 371, 498
DOI: 10.1016/j.jconrel.2024.06.010

Nanomedicine – advantages for their use in rheumatoid arthritis theranostics

Shuyi Xiao, Yufu Tang, Zhuang Lv, Yimu Lin and Liang Chen

Journal of Controlled Release, 2019, 316, 302
DOI: 10.1016/j.jconrel.2019.11.008

Nano - Based Therapeutic Strategies in Management of Rheumatoid Arthritis

Gunjan Nautiyal, Shiv Kant Sharma, Dhirender Kaushik and Parijat Pandey

NANOTEC, 2024, 18, 433
DOI: 10.2174/1872210517666230822100324

Self-assembled PEGylated micelles for precise and targeted drug delivery: Current challenges and future directions

Surekharani Sinha, Arpan Kumar Tripathi, Ashish Pandey, Poonam Naik, Aakansha Pandey and Vinay Sagar Verma

Biocatalysis and Agricultural Biotechnology, 2024, 60, 103296
DOI: 10.1016/j.bcab.2024.103296

Activatable Near-Infrared Fluorescent Organic Nanoprobe for Hypochlorous Acid Detection in the Early Diagnosis of Rheumatoid Arthritis

Suya Zhang, Lulu Ning, Zhihui Song, Xinyue Zhao, Feng Guan, Xiao-Feng Yang and Jianjian Zhang

Anal. Chem., 2022, 94, 5805
DOI: 10.1021/acs.analchem.1c05184

NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity

Feiyang Jin, Jing Qi, Minxia Zhu, Di Liu, Yuchan You, Gaofeng Shu, Yan Du, Jun Wang, Hui Yu, Mingchen Sun, Xiaoling Xu, Qiying Shen, Xiaoying Ying, Jiansong Ji and Yongzhong Du

ACS Appl. Mater. Interfaces, 2020, 12, 32372
DOI: 10.1021/acsami.0c07503

Targeted drug-delivery Systems in the Treatment of Rheumatoid Arthritis: Recent Advancement and Clinical Status

Srividya Gorantla, Gautam Singhvi, Vamshi Krishna Rapalli, Tejashree Waghule, Sunil Kumar Dubey and Ranendra Narayan Saha

Ther. Deliv., 2020, 11, 269
DOI: 10.4155/tde-2020-0029

A Luminol-Based Self-Illuminating Nanocage as a Reactive Oxygen Species Amplifier to Enhance Deep Tumor Penetration and Synergistic Therapy

Xiao-Ling Xu, Nan-Nan Zhang, Gao-Feng Shu, Di Liu, Jing Qi, Fei-Yang Jin, Jian-Song Ji and Yong-Zhong Du

ACS Nano, 2021, 15, 19394
DOI: 10.1021/acsnano.1c05891

CAQK modification enhances the targeted accumulation of metformin-loaded nanoparticles in rats with spinal cord injury

Ting Li, Pei Jing, Lingling Yang, Yujie Wan, Xingjie Du, Jun Wei, Meiling Zhou, Zhongbing Liu, Yan Lin and Zhirong Zhong

Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 41, 102526
DOI: 10.1016/j.nano.2022.102526

Highly Efficient Oral Iguratimod/Polyvinyl Alcohol Nanodrugs Fabricated by High‐Gravity Nanoprecipitation Technique for Treatment of Rheumatoid Arthritis

Cheng Tao, Feifei Li, Zhenzhen Ma, Xiaoming Li, Yali Zhang, Yuan Le, Jiexin Wang, Jinxia Zhao, Chaoyong Liu and Jianjun Zhang

Small, 2024, 20
DOI: 10.1002/smll.202304150

Active Anchoring Stimuli‐Responsive Nano‐Craft to Relieve Pulmonary Vasoconstriction by Targeting Smooth Muscle Cell for Hypoxic Pulmonary Hypertension Treatment

Mingxing Li, Xuwei Shang, Haiya Lou, Zixu Wang, Shanshan Xiang, Yihe Qiu, Fuqiang Hu, Fangying Yu and Hong Yuan

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202400113

Sialic Acid-Functionalized pH-Triggered Micelles for Enhanced Tumor Tissue Accumulation and Active Cellular Internalization of Orthotopic Hepatocarcinoma

Xiao-Ling Xu, Kong-Jun Lu, Meng-Lu Zhu, Yang-Long Du, Ya-Fang Zhu, Nan-Nan Zhang, Xiao-Juan Wang, Xu-Qi Kang, De-Min Xu, Xiao-Ying Ying, Ri-Sheng Yu, Chen-Ying Lu, Jian-Song Ji, Jian You and Yong-Zhong Du

ACS Appl. Mater. Interfaces, 2018, 10, 31903
DOI: 10.1021/acsami.8b09498

Combinational protective therapy for spinal cord injury medicated by sialic acid-driven and polyethylene glycol based micelles

Xiao-Juan Wang, Gao-Feng Shu, Xiao-Ling Xu, Chen-Han Peng, Chen-Ying Lu, Xing-Yao Cheng, Xiang-Chao Luo, Jie Li, Jing Qi, Xu-Qi Kang, Fei-Yang Jin, Min-Jiang Chen, Xiao-Ying Ying, Jian You, Yong-Zhong Du and Jian-Song Ji

Biomaterials, 2019, 217, 119326
DOI: 10.1016/j.biomaterials.2019.119326

Nanoparticle-Based Drug Delivery Systems for Induction of Tolerance and Treatment of Autoimmune Diseases

He Li, Yong-Guang Yang and Tianmeng Sun

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.889291

Adipose-derived stem cell exosomes loaded with icariin alleviates rheumatoid arthritis by modulating macrophage polarization in rats

Qiqi Yan, Haixia Liu, Shiyue Sun, Yongsheng Yang, DanPing Fan, Yuqin Yang, Yukun Zhao, Zhiqian Song, Yanjing Chen, Ruyuan Zhu and Zhiguo Zhang

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02711-1

Current reviews depicting therapeutic potential of novel drug delivery system in rheumatoid arthritis

Sricha Singh, Parul Pamma, Sujit Bose, Sapna Sharma, Sakshi Sharma and P.K. Prabhakar

BIO Web Conf., 2024, 86, 01035
DOI: 10.1051/bioconf/20248601035

Vaccine to Nano-Vaccine: Novel Technique to Treat Rheumatoid Arthritis

Sandip Zine, Dhanashri Kadam and Pranita Lodha

CRR, 2025, 21, 519
DOI: 10.2174/0115733971330575250121054355

Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases

Anne Bordron, Marie Morel, Cristina Bagacean, Maryvonne Dueymes, Pierre Pochard, Anne Harduin-Lepers, Christophe Jamin and Jacques-Olivier Pers

IJMS, 2021, 22, 3402
DOI: 10.3390/ijms22073402

Emerging nanotherapeutics alleviating rheumatoid arthritis by readjusting the seeds and soils

Wenjing Zhang, Yang Chen, Qin Liu, Mei Zhou, Kang Wang, Yongzhong Wang, Jiusheng Nie, Shuangying Gui, Daiyin Peng, Zhonggui He and Zhenbao Li

Journal of Controlled Release, 2022, 345, 851
DOI: 10.1016/j.jconrel.2022.04.001

Boosting Tumor Accumulation of Phthalocyanine through Sialylation Engineering for Superior Cancer Phototherapy

Jian Li, Tingting Wang, Cijuan Li, Xun Zhang, Jingchao Li, Dongsheng Zhang, Yafei Zhang, Jun Yang, Xinhui Su and Nian Liu

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202402381

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

Lu Liu, Weisheng Guo and Xing‐Jie Liang

Biotechnology Journal, 2019, 14
DOI: 10.1002/biot.201800024

Emerging drug delivery systems with traditional routes – A roadmap to chronic inflammatory diseases

Kiyoon Min, Abhishek Sahu, Sae Hyun Jeon and Giyoong Tae

Advanced Drug Delivery Reviews, 2023, 203, 115119
DOI: 10.1016/j.addr.2023.115119

Apatite‐Binding Nanoparticulate Agonist of Hedgehog Signaling for Bone Repair

Xiao Zhang, Jiabing Fan, Chung‐Sung Lee, Soyon Kim, Chen Chen, Tara Aghaloo and Min Lee

Adv Funct Materials, 2020, 30
DOI: 10.1002/adfm.201909218

Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis

Nirmal Marasini, Gerald Er, Changkui Fu, Christopher N. Subasic, Jibriil Ibrahim, Mariusz Skwarczynski, Istvan Toth, Andrew K. Whittaker and Lisa M. Kaminskas

Acta Biomaterialia, 2022, 142, 298
DOI: 10.1016/j.actbio.2022.01.054

Nanomedicine is more than a supporting role in rheumatoid arthritis therapy

Yu Han and Shilei Huang

Journal of Controlled Release, 2023, 356, 142
DOI: 10.1016/j.jconrel.2023.02.035

A comprehensive review of advanced drug delivery systems for the treatment of rheumatoid arthritis

Qiying Shen and Yongzhong Du

International Journal of Pharmaceutics, 2023, 635, 122698
DOI: 10.1016/j.ijpharm.2023.122698

Nanomedicines for the treatment of rheumatoid arthritis: State of art and potential therapeutic strategies

Qin Wang, Xianyan Qin, Jiyu Fang and Xun Sun

Acta Pharmaceutica Sinica B, 2021, 11, 1158
DOI: 10.1016/j.apsb.2021.03.013

Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment

Chunhong Li, Xiu Zheng, Mei Hu, Ming Jia, Rongrong Jin and Yu Nie

Expert Opinion on Drug Delivery, 2022, 19, 883
DOI: 10.1080/17425247.2022.2094364

Sialic acid-engineered mesoporous polydopamine nanoparticles loaded with SPIO and Fe3+ as a novel theranostic agent for T1/T2 dual-mode MRI-guided combined chemo-photothermal treatment of hepatic cancer

Gaofeng Shu, Minjiang Chen, Jingjing Song, Xiaoling Xu, Chenying Lu, Yuyin Du, Min Xu, Zhongwei Zhao, Minxia Zhu, Kai Fan, Xiaoxi Fan, Shiji Fang, Bufu Tang, Yiyang Dai, Yongzhong Du and Jiansong Ji

Bioactive Materials, 2021, 6, 1423
DOI: 10.1016/j.bioactmat.2020.10.020

Nanomedicine targeted anti-inflammatory therapy to deal with the ‘crux’ of rheumatoid arthritis

Min An, Juntao Zhang, Xiaojie Zhang, Yumeng Zhao and Yanhua Liu

Journal of Drug Targeting, 2024, 32, 381
DOI: 10.1080/1061186X.2024.2315475

The in vivo fate of polymeric micelles

Yifan Cai, Jianping Qi, Yi Lu, Haisheng He and Wei Wu

Advanced Drug Delivery Reviews, 2022, 188, 114463
DOI: 10.1016/j.addr.2022.114463

Drug Delivery System Approaches for Rheumatoid Arthritis Treatment: A Review

Anushka Garhwal, Priyadarshi Kendya, Sakshi Soni, Shivam Kori, Vandana Soni and Sushil Kumar Kashaw

MRMC, 2024, 24, 704
DOI: 10.2174/1389557523666230913105803

Sialic Acid‐Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy

Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu and Yongzhong Du

Small, 2024, 20
DOI: 10.1002/smll.202306905

Energy Conversion-Based Nanotherapy for Rheumatoid Arthritis Treatment

Pingping Wang, Ao Li, Luodan Yu, Yu Chen and Di Xu

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00652

New Generation Smart Drug Delivery Systems for Rheumatoid Arthritis

Raghuraj Singh, Krishna Jadhav, Kalpesh Vaghasiya, Eupa Ray, Rahul Shukla and Rahul Kumar Verma

CPD, 2023, 29, 984
DOI: 10.2174/1381612829666230406102935

A Melanin-like Nanoenzyme for Acute Lung Injury Therapy via Suppressing Oxidative and Endoplasmic Reticulum Stress Response

Xue-Fang Lou, Chen Wang, Ju-Cong Zhang, Yong-Zhong Du and Xiao-Ling Xu

Pharmaceutics, 2021, 13, 1850
DOI: 10.3390/pharmaceutics13111850

Design and application of dextran carrier

Shiyu Huang and Gangliang Huang

Journal of Drug Delivery Science and Technology, 2020, 55, 101392
DOI: 10.1016/j.jddst.2019.101392

Sialylation: An alternative to designing long-acting and targeted drug delivery system

Qixiong Zhang, Shanshan Li, Rongsheng Tong and Yuxuan Zhu

Biomedicine & Pharmacotherapy, 2023, 166, 115353
DOI: 10.1016/j.biopha.2023.115353

Nanoparticle-Based Drug Delivery Systems for Enhancing Bone Regeneration

Hang Xu, Yutao Cui, Yuhang Tian, Minghan Dou, Shouye Sun, Jingwei Wang and Dankai Wu

ACS Biomater. Sci. Eng., 2024, 10, 1302
DOI: 10.1021/acsbiomaterials.3c01643

Nanotechnology-empowered combination therapy for rheumatoid arthritis: principles, strategies, and challenges

Shujing Ren, Yuhang Xu, Xingpeng Dong, Qingxin Mu, Xia Chen, Yanyan Yu and Gaoxing Su

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02670-7

Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy

Lina Guo, Yang Chen, Ting Wang, Yu Yuan, Yihua Yang, Xiaoli Luo, Shuo Hu, Jinsong Ding and Wenhu Zhou

Journal of Controlled Release, 2021, 330, 119
DOI: 10.1016/j.jconrel.2020.10.069

Sinomenine hydrochloride loaded thermosensitive liposomes combined with microwave hyperthermia for the treatment of rheumatoid arthritis

Qiying Shen, Xinzhong Zhang, Jing Qi, Gaofeng Shu, Yongzhong Du and Xiaoying Ying

International Journal of Pharmaceutics, 2020, 576, 119001
DOI: 10.1016/j.ijpharm.2019.119001

Molecular architectonics of semiconducting polymer dots for next-generation NIR-II fluorescence bioimaging

Nabil Omri and Vignesh Kumaravel

Nano Today, 2026, 68, 103016
DOI: 10.1016/j.nantod.2026.103016

Highly Integrated Nanoplatform Based on an E-Selectin-Targeting Strategy for Metastatic Breast Cancer Treatment

Xiao-Ling Xu, Meng-Lu Zhu, Di Liu, Gao-Feng Shu, Jing Qi, Yan Lu, Fei Wang, Xiao-Ying Ying, Jian Chen and Yong-Zhong Du

Mol. Pharmaceutics, 2019, 16, 3694
DOI: 10.1021/acs.molpharmaceut.9b00616

Drug Targeting and Nanotherapeutic Advancement in the Treatment of Rheumatoid Arthritis: Recent Progress in Drug Delivery Systems

Rohitas Deshmukh

CPB, 2025, 26, 1459
DOI: 10.2174/0113892010306005240605072550