Halogenases and dehalogenases: mechanisms, engineering, and applications

Jing Luo, Na Li, Jia Wang, Yaojie Gao, Hongzhi Tang, Linquan Bai, Sang Yup Lee and Yaojun Tong

Nat. Prod. Rep., 2026, 43, 427
DOI: 10.1039/D5NP00055F

Halofunctionalization of alkenes by vanadium chloroperoxidase from Curvularia inaequalis

Jia Jia Dong, Elena Fernández-Fueyo, Jingbo Li, Zheng Guo, Rokus Renirie, Ron Wever and Frank Hollmann

Chem. Commun., 2017, 53, 6207
DOI: 10.1039/C7CC03368K

Dibromination of alkenes with LiBr and H2O2under mild conditions

Nayara Silva Martins and Eduardo E. Alberto

New J. Chem., 2018, 42, 161
DOI: 10.1039/C7NJ04300G

Hydrogen peroxide driven biocatalysis

B. O. Burek, S. Bormann, F. Hollmann, J. Z. Bloh and D. Holtmann

Green Chem., 2019, 21, 3232
DOI: 10.1039/C9GC00633H

Synthesis of silver and gold nanoparticles–enzyme–polymer conjugate hybrids as dual-activity catalysts for chemoenzymatic cascade reactions

Janne M. Naapuri, Noelia Losada-Garcia, Jan Deska and Jose M. Palomo

Nanoscale, 2022, 14, 5701
DOI: 10.1039/D2NR00361A

Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation

Charlotte Crowe, Samuel Molyneux, Sunil V. Sharma, Ying Zhang, Danai S. Gkotsi, Helen Connaris and Rebecca J. M. Goss

Chem. Soc. Rev., 2021, 50, 9443
DOI: 10.1039/D0CS01551B

Haloperoxidases as catalysts in organic synthesis

Georg T. Höfler, Andrada But and Frank Hollmann

Org. Biomol. Chem., 2019, 17, 9267
DOI: 10.1039/C9OB01884K

Biocatalysis making waves in organic chemistry

Ulf Hanefeld, Frank Hollmann and Caroline E. Paul

Chem. Soc. Rev., 2022, 51, 594
DOI: 10.1039/D1CS00100K

Peroxidase-induced C–N bond formation via nitroso ene and Diels–Alder reactions

Christina Jäger, Bernhard J. Gregori, Juhana A. S. Aho, Marleen Hallamaa and Jan Deska

Green Chem., 2023, 25, 3166
DOI: 10.1039/D2GC04827B

Asymmetric ring contraction of 2-hydroxypyranones by borrowing hydrogen biocatalysis

Yuchang Liu, Adam O'Connell, J. D. Rolfes and Jan Deska

Chem. Sci., 2025, 16, 17667
DOI: 10.1039/D5SC02591E

Chiral Nonaromatic Nitrogen-Heterocycles by Asymmetric Intramolecular Haloamination and Haloamidation

Mario Orena and Samuele Rinaldi

Organics, 2024, 5, 163
DOI: 10.3390/org5030009

Cascade Catalysis Through Bifunctional Lipase Metal Biohybrids for the Synthesis of Enantioenriched O‐Heterocycles from Allenes

Janne M. Naapuri, Noelia Losada‐Garcia, Robin Alexander Rothemann, Manuel Carmona Pichardo, Martin H. G. Prechtl, Jose M. Palomo and Jan Deska

ChemCatChem, 2022, 14
DOI: 10.1002/cctc.202200362

Electrochemical Cyclization of 2,3-Allenols

Wenyao Li, Dong Huang, Zhuowei Xu, Zhongshuo Zhang, Ying Wang, Hao Yu and Shengming Ma

Org. Lett., 2025, 27, 3506
DOI: 10.1021/acs.orglett.5c00193

Kirmse–Doyle‐ and Stevens‐Type Rearrangements of Glutarate‐Derived Oxonium Ylides

Benedikt Skrobo, Nils E. Schlörer, Jörg‐M. Neudörfl and Jan Deska

Chemistry A European J, 2018, 24, 3209
DOI: 10.1002/chem.201704624

Arylative Allenol Cyclization via Sequential One‐pot Enzyme & Palladium Catalysis

Janne M. Naapuri, Gustav A. Åberg, Jose M. Palomo and Jan Deska

ChemCatChem, 2021, 13, 763
DOI: 10.1002/cctc.202001619

Choline Oxidase and Choline Ionic Liquids in Biocatalytic Heme Peroxidase Cascades

Marleen Hallamaa, Janne M. Naapuri, Rafaela A. L. Silva, Andreia A. Rosatella and Jan Deska

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202401216

Regio- and Diastereoselective Synthesis of Dihydropyrans and Pyranopyrans via Oxonium–Ene Reaction of β-Allenols and Aldehydes

Ngangbam Renubala Devi, Sabera Sultana, Madhurjya Borah and Anil K. Saikia

J. Org. Chem., 2018, 83, 14987
DOI: 10.1021/acs.joc.8b02244

Coding Synthetic Chemistry Strategies for Furan Valorization into Bacterial Designer Cells**

Yu‐Chang Liu, Zhong‐Liu Wu and Jan Deska

ChemSusChem, 2023, 16
DOI: 10.1002/cssc.202201790

Enantiokonvergente biokatalytische Redoxisomerisierung

Yu‐Chang Liu, Christian Merten and Jan Deska

Angewandte Chemie, 2018, 130, 12328
DOI: 10.1002/ange.201804911

Enzymatic Bromocyclization of α‐ and γ‐Allenols by Chloroperoxidase from Curvularia inaequalis

Janne M. Naapuri, Philip K. Wagner, Frank Hollmann and Jan Deska

ChemistryOpen, 2022, 11
DOI: 10.1002/open.202100236

Recent developments in the use of peroxygenases – Exploring their high potential in selective oxyfunctionalisations

Markus Hobisch, Dirk Holtmann, Patricia Gomez de Santos, Miguel Alcalde, Frank Hollmann and Selin Kara

Biotechnology Advances, 2021, 51, 107615
DOI: 10.1016/j.biotechadv.2020.107615

Flavin-dependent halogenases catalyze enantioselective olefin halocyclization

Dibyendu Mondal, Brian F. Fisher, Yuhua Jiang and Jared C. Lewis

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-23503-3

Aerobe C‐N‐Bindungsknüpfung durch enzymatische Nitroso‐En‐Reaktionen**

Christina Jäger, Mona Haase, Katja Koschorreck, Vlada B. Urlacher and Jan Deska

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202213671

Chemoenzymatic Cyclization by Vanadium Chloroperoxidase for Synthesis of 4‐Hydroxyisochroman‐1‐Ones

Chisanu Krongyut, Nittaya Wiriya, Worakrit Saiyasombat, Kantapat Chansaenpak, Sineenat Sripattanakul, Anyanee Kamkaew and Rung‐Yi Lai

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400697

Elevating Haloperoxidase Expression in Escherichia coli through Fusion with a Formate Oxidase

Angelique Pothuizen, Jacob M. A. van Hengst, Ron Wever, Peter-Leon Hagedoorn and Frank Hollmann

ChemBioChem, 2026, 27
DOI: 10.1002/cbic.70322

Enantioconvergent Biocatalytic Redox Isomerization

Yu‐Chang Liu, Christian Merten and Jan Deska

Angew Chem Int Ed, 2018, 57, 12151
DOI: 10.1002/anie.201804911

From Reactive Oxygen Species to Reactive Brominating Species: Fenton Chemistry for Oxidative Bromination

Guodong Zhao, Eryu Wang and Rongbiao Tong

ACS Sustainable Chem. Eng., 2021, 9, 6118
DOI: 10.1021/acssuschemeng.1c01709

Flavin‐Dependent Halogenases: Emerging Enzymes and New Functions

Kridsadakorn Prakinee, Watcharapa Jitkaroon and Pimchai Chaiyen

ChemCatChem, 2025, 17
DOI: 10.1002/cctc.202500558

Enzymatic halogenation and oxidation using an alcohol oxidase-vanadium chloroperoxidase cascade

Andrada But, Aster van Noord, Francesca Poletto, Johan P.M. Sanders, Maurice C.R. Franssen and Elinor L. Scott

Molecular Catalysis, 2017, 443, 92
DOI: 10.1016/j.mcat.2017.09.014

Cu-catalyzed three-component C S P coupling for the synthesis of trisubstituted allenyl phosphorothioates

Bowen Wang, Longwu Sun, Qianqian Cao, Xinzhi Li, Jianai Chen, Shizhao Wang, Miaolin Ke and Fener Chen

Chinese Chemical Letters, 2024, 35, 109617
DOI: 10.1016/j.cclet.2024.109617

Chemoenzymatic Total Synthesis of (+)- & (−)-cis-Osmundalactone

Fabian Blume, Yu-Chang Liu, Daniel Thiel and Jan Deska

Journal of Molecular Catalysis B: Enzymatic, 2016, 134, 280
DOI: 10.1016/j.molcatb.2016.11.010

Recent Advances in Sequentially Pd-Catalyzed One-Pot Syntheses of Heterocycles

Maryna M. Kornet and Thomas J. J. Müller

Molecules, 2024, 29, 5265
DOI: 10.3390/molecules29225265

Chemoenzymatic Halocyclization of γ,δ‐Unsaturated Carboxylic Acids and Alcohols

Sabry H. H. Younes, Florian Tieves, Dongming Lan, Yonghua Wang, Philipp Süss, Henrike Brundiek, Ron Wever and Frank Hollmann

ChemSusChem, 2020, 13, 97
DOI: 10.1002/cssc.201902240

Recent trends in the identification and engineering of halogenases

Huibin Wang and Ikuro Abe

Tetrahedron Chem, 2024, 12, 100112
DOI: 10.1016/j.tchem.2024.100112

Halogenating Enzymes for Active Agent Synthesis: First Steps Are Done and Many Have to Follow

Alexander Veljko Fejzagić, Jan Gebauer, Nikolai Huwa and Thomas Classen

Molecules, 2019, 24, 4008
DOI: 10.3390/molecules24214008

Methanol-Driven Oxidative Rearrangement of Biogenic Furans – Enzyme Cascades vs. Photobiocatalysis

Christina Jäger, Cloé Bruneau, Philip K. Wagner, Martin H. G. Prechtl and Jan Deska

Front. Chem., 2021, 9
DOI: 10.3389/fchem.2021.635883

Aerobic C−N Bond Formation through Enzymatic Nitroso‐Ene‐Type Reactions**

Christina Jäger, Mona Haase, Katja Koschorreck, Vlada B. Urlacher and Jan Deska

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202213671