Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones

Natalee J. Smith, Katarina Rohlfing, Lisa A. Sawicki, Prathamesh M. Kharkar, Samantha J. Boyd, April M. Kloxin and Joseph M. Fox

Org. Biomol. Chem., 2018, 16, 2164
DOI: 10.1039/C8OB00166A

Synthetic hydrogels formed by thiol–ene crosslinking of vinyl sulfone-functional poly(methyl vinyl ether-alt-maleic acid) with α,ω-dithio-polyethyleneglycol

S. A. Stewart, M. B. Coulson, C. Zhou, N. A. D. Burke and H. D. H. Stöver

Soft Matter, 2018, 14, 8317
DOI: 10.1039/C8SM01066H

Spatiotemporal hydrogel biomaterials for regenerative medicine

Tobin E. Brown and Kristi S. Anseth

Chem. Soc. Rev., 2017, 46, 6532
DOI: 10.1039/C7CS00445A

Controlled release and corrosion protection by self-assembled colloidal particles electrodeposited onto magnesium alloys

Jiadi Sun, Ye Zhu, Long Meng, Wei Wei, Yang Li, Xiaoya Liu and Yufeng Zheng

J. Mater. Chem. B, 2015, 3, 1667
DOI: 10.1039/C4TB01683A

Dual-stimuli-responsive glycopolymer bearing a reductive and photo-cleavable unit at block junction

Jia-You Fang, Yin-Ku Lin, Shiu-Wei Wang, Yung-Ching Yu and Ren-Shen Lee

RSC Adv., 2016, 6, 107669
DOI: 10.1039/C6RA22207B

Structure–reactivity based control of radical-mediated degradation in thiol–Michael hydrogels

Bruce E. Kirkpatrick, Miranda T. Rubio, Tvishi Yendamuri, Naomi V. Elmer, Danielle S. W. Benoit, C. Allan Guymon, Kristi S. Anseth and Tayler S. Hebner

J. Mater. Chem. B, 2025, 13, 10177
DOI: 10.1039/D5TB01237F

PEG-based hydrogels prepared by catalyst-free thiol–yne addition and their post-antibacterial modification

Xiao Yan Cai, Jun Zhi Li, Ning Ning Li, Jiu Cun Chen, En-Tang Kang and Li Qun Xu

Biomater. Sci., 2016, 4, 1663
DOI: 10.1039/C6BM00395H

Photoactive hydrogels for pre-concentration, labelling, and controlled release of proteins

Leanne Kellermann and Ruchi Gupta

Analyst, 2023, 148, 4127
DOI: 10.1039/D3AN00811H

Modular and orthogonal synthesis of hybrid polymers and networks

Shuang Liu, Kevin T. Dicker and Xinqiao Jia

Chem. Commun., 2015, 51, 5218
DOI: 10.1039/C4CC09568E

Stimuli-responsive destructible polymeric hydrogels based on irreversible covalent bond dissociation

Sina Shahi, Hossein Roghani-Mamaqani, Saeid Talebi and Hanieh Mardani

Polym. Chem., 2022, 13, 161
DOI: 10.1039/D1PY01066B

Design of thiol- and light-sensitive degradable hydrogels using Michael-type addition reactions

Prathamesh M. Kharkar, Kristi L. Kiick and April M. Kloxin

Polym. Chem., 2015, 6, 5565
DOI: 10.1039/C5PY00750J

Effect of Crosslinker Topology on Enzymatic Degradation of Hydrogels

Yulia Shmidov, Yumeng Zhu, John B. Matson and Ronit Bitton

Biomacromolecules, 2020, 21, 3279
DOI: 10.1021/acs.biomac.0c00722

Fabrication, GSH-responsive drug release, and anticancer properties of thioctic acid-based intelligent hydrogels

Hui Liu, Zhiwei Deng, Tianhao Li, Jiaqi Bu, De Wang, Jiahui Wang, Meng Liu, Jiacheng Li, Yanjing Yang and Shian Zhong

Colloids and Surfaces B: Biointerfaces, 2022, 217, 112703
DOI: 10.1016/j.colsurfb.2022.112703

Thiol–ene Click Hydrogels for Therapeutic Delivery

Prathamesh M. Kharkar, Matthew S. Rehmann, Kelsi M. Skeens, Emanual Maverakis and April M. Kloxin

ACS Biomater. Sci. Eng., 2016, 2, 165
DOI: 10.1021/acsbiomaterials.5b00420

Biomaterials for 4D stem cell culture

Amber M. Hilderbrand, Elisa M. Ovadia, Matthew S. Rehmann, Prathamesh M. Kharkar, Chen Guo and April M. Kloxin

Current Opinion in Solid State and Materials Science, 2016, 20, 212
DOI: 10.1016/j.cossms.2016.03.002

Opportunities for Multicomponent Hybrid Hydrogels in Biomedical Applications

Hang Kuen Lau and Kristi L. Kiick

Biomacromolecules, 2015, 16, 28
DOI: 10.1021/bm501361c

Recent advances of on-demand dissolution of hydrogel dressings

Hao Lu, Long Yuan, Xunzhou Yu, Chengzhou Wu, Danfeng He and Jun Deng

Burns & Trauma, 2018, 6
DOI: 10.1186/s41038-018-0138-8

4D Printing of Extrudable and Degradable Poly(Ethylene Glycol) Microgel Scaffolds for Multidimensional Cell Culture

Connor E. Miksch, Nathaniel P. Skillin, Bruce E. Kirkpatrick, Grace K. Hach, Varsha V. Rao, Timothy J. White and Kristi S. Anseth

Small, 2022, 18
DOI: 10.1002/smll.202200951

Validation and application of a nondestructive and contactless method for rheological evaluation of biomaterials

Caroline Ceccaldi, Satu Strandman, Eve Hui, Emmanuel Montagnon, Cédric Schmitt, Anis Hadj Henni and Sophie Lerouge

J Biomed Mater Res, 2017, 105, 2565
DOI: 10.1002/jbm.b.33797

Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration

Xinming Tong and Fan Yang

Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201701065

A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon

Yingzheng Zhao, Pengpeng Xue, Gaolong Lin, Mengqi Tong, Jiaojiao Yang, Yingying Zhang, Kunjie Ran, Deli Zhuge, Qing Yao and Helin Xu

Acta Biomaterialia, 2022, 143, 233
DOI: 10.1016/j.actbio.2022.02.039

Decreasing matrix modulus of PEG hydrogels induces a vascular phenotype in human cord blood stem cells

Shruthi Mahadevaiah, Karyn G. Robinson, Prathamesh M. Kharkar, Kristi L. Kiick and Robert E. Akins

Biomaterials, 2015, 62, 24
DOI: 10.1016/j.biomaterials.2015.05.021

On‐Demand Photodegradable and Thermo‐Reversible, Soft, Transparent Dithioacetal Hydrogels

Maria Psarrou, Ioanna Chatzaki, Antonis Mavromanolakis, Theodore Manouras, Dimitris Vlassopoulos and Maria Vamvakaki

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202508160

Fast-Forming Dissolvable Redox-Responsive Hydrogels: Exploiting the Orthogonality of Thiol–Maleimide and Thiol–Disulfide Exchange Chemistry

Ismail Altinbasak, Salli Kocak, Rana Sanyal and Amitav Sanyal

Biomacromolecules, 2022, 23, 3525
DOI: 10.1021/acs.biomac.2c00209

Diverse reactivity of maleimides in polymer science and beyond

Bruce E Kirkpatrick, Kristi S Anseth and Tayler S Hebner

Polymer International, 2025, 74, 296
DOI: 10.1002/pi.6715

Chondroitin sulfate/silk fibroin hydrogel incorporating graphene oxide quantum dots with photothermal-effect promotes type H vessel-related wound healing

Tanjun Deng, Wenli Lu, Xiaoxian Zhao, Haoyu Wang, Yumeng Zheng, Ao Zheng and Zhengyu Shen

Carbohydrate Polymers, 2024, 334, 121972
DOI: 10.1016/j.carbpol.2024.121972

Tuning and Predicting Mesh Size and Protein Release from Step Growth Hydrogels

Matthew S. Rehmann, Kelsi M. Skeens, Prathamesh M. Kharkar, Eden M. Ford, Emanual Maverakis, Kelvin H. Lee and April M. Kloxin

Biomacromolecules, 2017, 18, 3131
DOI: 10.1021/acs.biomac.7b00781

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

Giovanna Brusatin, Tito Panciera, Alessandro Gandin, Anna Citron and Stefano Piccolo

Nature Mater, 2018, 17, 1063
DOI: 10.1038/s41563-018-0180-8

Deformable microparticles for shuttling nanoparticles to the vascular wall

Margaret B. Fish, Alison L. Banka, Margaret Braunreuther, Catherine A. Fromen, William J. Kelley, Jonathan Lee, Reheman Adili, Michael Holinstat and Omolola Eniola-Adefeso

Sci. Adv., 2021, 7
DOI: 10.1126/sciadv.abe0143

Sustained Delivery of Lactoferrin Using Poloxamer Gels for Local Bone Regeneration in a Rat Calvarial Defect Model

Young Eun Park, Kaushik Chandramouli, Maureen Watson, Mark Zhu, Karen E. Callon, Donna Tuari, Hani Abdeltawab, Darren Svirskis, David Shaun Musson, Manisha Sharma and Jillian Cornish

Materials, 2021, 15, 212
DOI: 10.3390/ma15010212

Colloidal Quantum Dots: Synthesis, Composition, Structure, and Emerging Optoelectronic Applications

Jian Zhang, Shaohui Zhang, Yule Zhang, Omar A. Al‐Hartomy, Swelm Wageh, Abdullah G. Al‐Sehemi, Yabin Hao, Lingfeng Gao, Hao Wang and Han Zhang

Laser & Photonics Reviews, 2023, 17
DOI: 10.1002/lpor.202200551

Oxygen Inhibition of Radical Polymerizations Investigated with the Rheometric Quartz Crystal Microbalance

C. Joshua Yeh, Michael Hu and Kenneth R. Shull

Macromolecules, 2018, 51, 5511
DOI: 10.1021/acs.macromol.8b00720

Sulfur Chemistry in Polymer and Materials Science

Hatice Mutlu, Ezgi Berfin Ceper, Xiaohui Li, Jingmei Yang, Wenyuan Dong, Mehmet Murat Ozmen and Patrick Theato

Macromol. Rapid Commun., 2019, 40
DOI: 10.1002/marc.201800650

Amino-yne Reaction for the Synthesis of Degradable Hydrogels: Study of the Cleavage of β-Aminoacrylate Cross-Links

Sara Bescós-Ramo, Jesús del Barrio, Pilar Romero, Laura Florentino-Madiedo, Milagros Piñol and Luis Oriol

Macromolecules, 2024, 57, 10926
DOI: 10.1021/acs.macromol.4c01403

Hydrogel-Mediated Sustained Systemic Delivery of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improves Hepatic Regeneration in Chronic Liver Failure

Soura Mardpour, Mohammad Hossein Ghanian, Hamid Sadeghi-abandansari, Saeid Mardpour, Abdoreza Nazari, Faezeh Shekari and Hossein Baharvand

ACS Appl. Mater. Interfaces, 2019, 11, 37421
DOI: 10.1021/acsami.9b10126

On‐Demand Photodegradable and Thermo‐Reversible, Soft, Transparent Dithioacetal Hydrogels

Maria Psarrou, Ioanna Chatzaki, Antonis Mavromanolakis, Theodore Manouras, Dimitris Vlassopoulos and Maria Vamvakaki

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202508160

Thiol-Methylsulfone-Based Hydrogels for 3D Cell Encapsulation

Julieta I. Paez, Aleeza Farrukh, Rocío Valbuena-Mendoza, Małgorzata K. Włodarczyk-Biegun and Aránzazu del Campo

ACS Appl. Mater. Interfaces, 2020, 12, 8062
DOI: 10.1021/acsami.0c00709

3D Cell Culture Models as Recapitulators of the Tumor Microenvironment for the Screening of Anti-Cancer Drugs

Mélanie A. G. Barbosa, Cristina P. R. Xavier, Rúben F. Pereira, Vilma Petrikaitė and M. Helena Vasconcelos

Cancers, 2021, 14, 190
DOI: 10.3390/cancers14010190

Injectable Hydrogels for Cancer Therapy over the Last Decade

Giuseppe Cirillo, Umile Gianfranco Spizzirri, Manuela Curcio, Fiore Pasquale Nicoletta and Francesca Iemma

Pharmaceutics, 2019, 11, 486
DOI: 10.3390/pharmaceutics11090486

Embedding Thiols into Choline Phosphate Polymer Zwitterions

Deborah Snyder and Todd Emrick

Macromol. Rapid Commun., 2024, 45
DOI: 10.1002/marc.202300690

Degradable hydrogels: Design mechanisms and versatile applications

B. Hosseinzadeh and M. Ahmadi

Materials Today Sustainability, 2023, 23, 100468
DOI: 10.1016/j.mtsust.2023.100468

Redox-Responsive Drug Delivery Systems: A Chemical Perspective

Heba F. Abed, Waad H. Abuwatfa and Ghaleb A. Husseini

Nanomaterials, 2022, 12, 3183
DOI: 10.3390/nano12183183

Controlling the Release of Small, Bioactive Proteins via Dual Mechanisms with Therapeutic Potential

Prathamesh M. Kharkar, Rebecca A. Scott, Laura P. Olney, Paige J. LeValley, Emanual Maverakis, Kristi L. Kiick and April M. Kloxin

Adv Healthcare Materials, 2017, 6
DOI: 10.1002/adhm.201700713

Biosynthetic Polymers as Functional Materials

Andrea S. Carlini, Lisa Adamiak and Nathan C. Gianneschi

Macromolecules, 2016, 49, 4379
DOI: 10.1021/acs.macromol.6b00439

Simultaneous Orthogonal Dual-Click Approach to Tough, in-Situ-Forming Hydrogels for Cell Encapsulation

Vinh X. Truong, Matthew P. Ablett, Stephen M. Richardson, Judith A. Hoyland and Andrew P. Dove

J. Am. Chem. Soc., 2015, 137, 1618
DOI: 10.1021/ja511681s

Biomaterials for neuroengineering: applications and challenges

Huanghui Wu, Enduo Feng, Huanxin Yin, Yuxin Zhang, Guozhong Chen, Beier Zhu, Xuezheng Yue, Haiguang Zhang, Qiong Liu and Lize Xiong

Regenerative Biomaterials, 2025, 12
DOI: 10.1093/rb/rbae137

Role of Hyaluronic Acids and Potential as Regenerative Biomaterials in Wound Healing

Hao Yang, Liu Song, Yifang Zou, Dandan Sun, Limei Wang, Zhuo Yu and Jianfeng Guo

ACS Appl. Bio Mater., 2021, 4, 311
DOI: 10.1021/acsabm.0c01364

50th Anniversary Perspective: Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry

Yingkai Liang, Linqing Li, Rebecca A. Scott and Kristi L. Kiick

Macromolecules, 2017, 50, 483
DOI: 10.1021/acs.macromol.6b02389

Click-formed polymer gels with aggregation-induced emission and dual stimuli-responsive behaviors

Sheng-yu Shi and Guo-ying Zhang

Chinese Journal of Chemical Physics, 2021, 34, 365
DOI: 10.1063/1674-0068/cjcp2006090

Controlled release of an anthrax toxin‐neutralizing antibody from hydrolytically degradable polyethylene glycol hydrogels

Yingkai Liang, Megan V. Coffin, Slobodanka D. Manceva, Jessica A. Chichester, R. Mark Jones and Kristi L. Kiick

J Biomedical Materials Res, 2016, 104, 113
DOI: 10.1002/jbm.a.35545

Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine

Michael Hacker and Hafiz Nawaz

IJMS, 2015, 16, 27677
DOI: 10.3390/ijms161126056

Imine Hydrogels with Tunable Degradability for Tissue Engineering

Natalie Boehnke, Cynthia Cam, Erhan Bat, Tatiana Segura and Heather D. Maynard

Biomacromolecules, 2015, 16, 2101
DOI: 10.1021/acs.biomac.5b00519

Recent advances in hydrogel-based drug delivery systems for enhanced cancer therapy: A review

Fatemeh Davodabadi, Saman Sargazi and Francesco Baino

Materials Today Communications, 2025, 48, 113615
DOI: 10.1016/j.mtcomm.2025.113615

Smart nanohydrogels for drug delivery: a comprehensive review

Amirhosein Abi, Zahra Mohammadi and Niloofar Eslahi

Polym. Bull., 2026, 83
DOI: 10.1007/s00289-026-06302-y

Resilin-PEG Hybrid Hydrogels Yield Degradable Elastomeric Scaffolds with Heterogeneous Microstructure

Christopher L. McGann, Robert E. Akins and Kristi L. Kiick

Biomacromolecules, 2016, 17, 128
DOI: 10.1021/acs.biomac.5b01255

Stability of proteins encapsulated in Michael‐type addition polyethylene glycol hydrogels

Zahra Ghassemi, Samuel Ruesing, Jennie B. Leach and Silviya P. Zustiak

Biotech & Bioengineering, 2021, 118, 4840
DOI: 10.1002/bit.27949

Molecular Engineering Mechanically Programmable Hydrogels with Orthogonal Functionalization

Lizhu Wang, Liang Zhu, Michael Hickner and Baojun Bai

Chem. Mater., 2017, 29, 9981
DOI: 10.1021/acs.chemmater.7b03398

Synthesis and characterization of thiol‐acrylate hydrogels using a base‐catalyzed Michael addition for 3D cell culture applications

Anowar H. Khan, Jeffery K. Cook, Wayne J. Wortmann, Nathan D. Kersker, Asha Rao, John A. Pojman and Adam T. Melvin

J Biomed Mater Res, 2020, 108, 2294
DOI: 10.1002/jbm.b.34565

Microgels Formed by Spontaneous Click Chemistries Utilizing Microfluidic Flow Focusing for Cargo Release in Response to Endogenous or Exogenous Stimuli

Paige J. LeValley, Amanda L. Parsons, Bryan P. Sutherland, Kristi L. Kiick, John S. Oakey and April M. Kloxin

Pharmaceutics, 2022, 14, 1062
DOI: 10.3390/pharmaceutics14051062

Enhanced Mechanical Properties in Cellulose Nanocrystal–Poly(oligoethylene glycol methacrylate) Injectable Nanocomposite Hydrogels through Control of Physical and Chemical Cross-Linking

Kevin J. De France, Katelyn J. W. Chan, Emily D. Cranston and Todd Hoare

Biomacromolecules, 2016, 17, 649
DOI: 10.1021/acs.biomac.5b01598

Liposome-Cross-Linked Hybrid Hydrogels for Glutathione-Triggered Delivery of Multiple Cargo Molecules

Yingkai Liang and Kristi L. Kiick

Biomacromolecules, 2016, 17, 601
DOI: 10.1021/acs.biomac.5b01541

Improved Mechanical Properties and Sustained Release Behavior of Cationic Cellulose Nanocrystals Reinforeced Cationic Cellulose Injectable Hydrogels

Jun You, Jinfeng Cao, Yanteng Zhao, Lina Zhang, Jinping Zhou and Yun Chen

Biomacromolecules, 2016, 17, 2839
DOI: 10.1021/acs.biomac.6b00646

Dynamic bioengineered hydrogels as scaffolds for advanced stem cell and organoid culture

Laura C. Bahlmann, Ana Fokina and Molly S. Shoichet

MRS Communications, 2017, 7, 472
DOI: 10.1557/mrc.2017.72

Achieving Controlled Biomolecule–Biomaterial Conjugation

Christopher D. Spicer, E. Thomas Pashuck and Molly M. Stevens

Chem. Rev., 2018, 118, 7702
DOI: 10.1021/acs.chemrev.8b00253