Issue 2, 2022

Synthesis of amidines via iron-catalyzed dearomative amination of β-naphthols with oxadiazolones

Abstract

An iron-catalyzed dearomative amination of β-naphthols via a nitrene-transfer process has been developed. Oxadiazolones, which have rarely been applied for the synthesis of amidines, are used as the nitrene source. A variety of amidines bearing β-naphthalenone moieties were generated smoothly in good to high yields (up to 98%) in the presence of 1.5 equivalents of tetrabutylammonium bromide, which was added as an essential additive.

Graphical abstract: Synthesis of amidines via iron-catalyzed dearomative amination of β-naphthols with oxadiazolones

Supplementary files

Article information

Article type
Research Article
Submitted
08 ኖቬም 2021
Accepted
28 ኖቬም 2021
First published
30 ኖቬም 2021

Org. Chem. Front., 2022,9, 380-385

Synthesis of amidines via iron-catalyzed dearomative amination of β-naphthols with oxadiazolones

Y. Fan, X. Guan, W. Li, C. Lin, D. Bing, M. Sun, G. Cheng, J. Cao, J. Chen and Q. Deng, Org. Chem. Front., 2022, 9, 380 DOI: 10.1039/D1QO01687C

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