Issue 17, 2021

Organocatalytic electrochemical amination of benzylic C–H bonds

Abstract

An organocatalytic site-selective electrochemical method for the benzylic C–H amination reactions of alkylarenes with azoles through hydrogen evolution has been developed. The protocol proceeds in an undivided cell under mild conditions and employs 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as a redox catalyst to generate carbocations, which obviates the need for transition-metal reagents or sacrificial chemical oxidants.

Graphical abstract: Organocatalytic electrochemical amination of benzylic C–H bonds

Supplementary files

Article information

Article type
Research Article
Submitted
13 ሜይ 2021
Accepted
28 ጁን 2021
First published
29 ጁን 2021

Org. Chem. Front., 2021,8, 4700-4705

Organocatalytic electrochemical amination of benzylic C–H bonds

Z. Hou, L. Li and L. Wang, Org. Chem. Front., 2021, 8, 4700 DOI: 10.1039/D1QO00746G

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