Issue 42, 2020

A minireview of viscosity-sensitive fluorescent probes: design and biological applications

Abstract

Microenvironment-related parameters like viscosity, polarity, and pH play important roles in controlling the physical or chemical behaviors of local molecules, which determine the physical or chemical behaviors of surrounding molecules. In general, changes of the internal microenvironment will usually lead to cellular malfunction or the occurrence of relevant diseases. In the last few decades, the field of chemicobiology has received great attention. Also, remarkable progress has been made in developing viscosity-sensitive fluorescent probes. These probes were particularly efficient for imaging viscosity in biomembranes as well as lighting up specific organelles, such as mitochondria and lysosome. Besides, there are some fluorescent probes that can be used to quantify intracellular viscosity when combined with fluorescence lifetime (FLIM) and ratiometric imaging under water-free conditions. In this review, we summarized the majority of viscosity-sensitive chemosensors that have been reported thus far.

Graphical abstract: A minireview of viscosity-sensitive fluorescent probes: design and biological applications

Article information

Article type
Review Article
Submitted
03 ሜይ 2020
Accepted
19 ጁላይ 2020
First published
02 ሴፕቴ 2020

J. Mater. Chem. B, 2020,8, 9642-9651

A minireview of viscosity-sensitive fluorescent probes: design and biological applications

C. Ma, W. Sun, L. Xu, Y. Qian, J. Dai, G. Zhong, Y. Hou, J. Liu and B. Shen, J. Mater. Chem. B, 2020, 8, 9642 DOI: 10.1039/D0TB01146K

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