Issue 4, 2020

Modification of proteins using olefin metathesis

Abstract

Olefin metathesis has revolutionized synthetic approaches to carbon–carbon bond formation. With a rich history beginning in industrial settings through its advancement in academic laboratories leading to new and highly active metathesis catalysts, olefin metathesis has found use in the generation of complex natural products, the cyclization of bioactive materials, and in the polymerization of new and unique polymer architectures. Throughout this review, we will trace the deployment of olefin metathesis-based strategies for the modification of proteins, a process which has been facilitated by the extensive development of stable, isolable, and highly active transition-metal-based metathesis catalysts. We first begin by summarizing early works which detail peptide modification strategies that played a vital role in identifying stable metathesis catalysts. We then delve into protein modification using cross metathesis and finish with recent work on the generation of protein–polymer conjugates through ring-opening metathesis polymerization.

Graphical abstract: Modification of proteins using olefin metathesis

Article information

Article type
Review Article
Submitted
01 ኦገስ 2019
Accepted
01 ጃንዩ 2020
First published
15 ጃንዩ 2020

Mater. Chem. Front., 2020,4, 1040-1051

Author version available

Modification of proteins using olefin metathesis

M. S. Messina and H. D. Maynard, Mater. Chem. Front., 2020, 4, 1040 DOI: 10.1039/C9QM00494G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements