A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Iaroslav Baglai; Michel Leeman; Richard M. Kellogg; Willem L. Noorduin

doi:10.1039/C8OB02660B

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam†

Iaroslav Baglai,^a Michel Leeman,^b Richard M. Kellogg^b and Willem L. Noorduin

*^a

Author affiliations

* Corresponding authors

^a AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands
E-mail: noorduin@amolf.nl

^b Syncom BV, Kadijk 3, 9747 AT Groningen, The Netherlands

Abstract

A simple route to enantiomerically pure (S)-2-aminobutyramide – the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.

This article is part of the themed collection: Mechanistic, computational & physical organic chemistry in OBC

Download options Please wait...

Supplementary files

Supplementary information PDF (660K)

Article information

DOI: https://doi.org/10.1039/C8OB02660B
Article type: Communication
Submitted: 26 ኦክቶ 2018
Accepted: 05 ኖቬም 2018
First published: 05 ኖቬም 2018

Download Citation

Org. Biomol. Chem., 2019,17, 35-38

Permissions

Request permissions

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

I. Baglai, M. Leeman, R. M. Kellogg and W. L. Noorduin, Org. Biomol. Chem., 2019, 17, 35 DOI: 10.1039/C8OB02660B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic & Biomolecular Chemistry

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Social activity

Search articles by author

Spotlight

Advertisements