Issue 1, 2018

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

Abstract

DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.

Graphical abstract: Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

Supplementary files

Article information

Article type
Communication
Submitted
24 ኦገስ 2017
Accepted
30 ኖቬም 2017
First published
07 ዲሴም 2017

Org. Biomol. Chem., 2018,16, 48-52

Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries

S. Matysiak, K. Hellmuth, A. H. El-Sagheer, A. Shivalingam, Y. Ariyurek, M. de Jong, M. J. Hollestelle, R. Out and T. Brown, Org. Biomol. Chem., 2018, 16, 48 DOI: 10.1039/C7OB02119D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements