Issue 24, 2017

The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

Abstract

Ruthenium(II) [Ru(II)] polypyridyl complexes have been the focus of intense investigations since work began exploring their supramolecular interactions with DNA. In recent years, there have been considerable efforts to translate this solution-based research into a biological environment with the intention of developing new classes of probes, luminescent imaging agents, therapeutics and theranostics. In only 10 years the field has expanded with diverse applications for these complexes as imaging agents and promising candidates for therapeutics. In light of these efforts this review exclusively focuses on the developments of these complexes in biological systems, both in cells and in vivo, and hopes to communicate to readers the diversity of applications within which these complexes have found use, as well as new insights gained along the way and challenges that researchers in this field still face.

Graphical abstract: The development of ruthenium(ii) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

Article information

Article type
Review Article
Submitted
21 ሴፕቴ 2017
First published
27 ኖቬም 2017

Chem. Soc. Rev., 2017,46, 7706-7756

The development of ruthenium(II) polypyridyl complexes and conjugates for in vitro cellular and in vivo applications

F. E. Poynton, S. A. Bright, S. Blasco, D. C. Williams, J. M. Kelly and T. Gunnlaugsson, Chem. Soc. Rev., 2017, 46, 7706 DOI: 10.1039/C7CS00680B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements