Issue 76, 2017

Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

Abstract

The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA–protein interactions triggered by the PS2 moiety.

Graphical abstract: Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

Supplementary files

Article information

Article type
Communication
Submitted
23 ጁላይ 2017
Accepted
28 ኦገስ 2017
First published
29 ኦገስ 2017

Chem. Commun., 2017,53, 10508-10511

Origins of the enhanced affinity of RNA–protein interactions triggered by RNA phosphorodithioate backbone modification

X. Yang, N. Dinuka Abeydeera, F. Liu and M. Egli, Chem. Commun., 2017, 53, 10508 DOI: 10.1039/C7CC05722A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements