Lyzu Yasmin, Travis Coyle, Keith A. Stubbs and Colin L. Raston
Chem. Commun., 2013,49, 10932-10934
DOI:
10.1039/C3CC45176C,
Communication
Acid catalysed condensation of resorcinol and pyrogallol with aromatic aldehydes using a microfluidic vortex fluidic device (VFD) under continuous flow conditions results in the selective formation of resorcin[4]arenes and pyrogallol[4]arenes as predominantly their C4v isomers. Notably C2v isomers and C2h isomers can be also prepared with the latter being converted to the C4v isomer when the VFD operates in confined mode.