Issue 30, 2012

Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation

Abstract

The mode of thioether macrocyclization of peptides containing an N-terminal 2-chloroacetyl group and two or three competing cysteine residues at downstream positions has been extensively studied, leading to a strategy for designated formation of overlapping-bicyclic peptides or dumbbell-type bicyclic peptides.

Graphical abstract: Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation

Supplementary files

Additions and corrections

Article information

Article type
Communication
Submitted
11 ፌብሩ 2012
Accepted
29 ፌብሩ 2012
First published
01 ማርች 2012

Org. Biomol. Chem., 2012,10, 5783-5786

Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation

K. Iwasaki, Y. Goto, T. Katoh and H. Suga, Org. Biomol. Chem., 2012, 10, 5783 DOI: 10.1039/C2OB25306B

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