Issue 8, 2022

A new cucurbit[10]uril-based AIE fluorescent supramolecular polymer for cellular imaging

Abstract

To further advance the development of cucurbit[10]uril-based supramolecular biomaterials, an AIE fluorescent supramolecular polymer (TPE-B@Q[10]) was constructed from the newly synthesized AIE molecule TPE-B and Q[10] via host–guest interactions in a host/guest ratio of 2 : 1. TPE-B@Q[10] not only has excellent blue fluorescence emission properties, but also possesses good biocompatibility and low toxicity. Therefore, TPE-B@Q[10] was successfully used for cytoplasmic imaging of cells. Flow cytometry further illustrated that Q[10] is capable of generating an alternative way to increase the fluorescence of TPE-B and its characteristic pattern for cellular imaging. This work provides a theoretical basis for promoting the application of cucurbit[n]uril-based supramolecular polymers in cell biology, and promotes the further development of cucurbit[n]uril chemistry.

Graphical abstract: A new cucurbit[10]uril-based AIE fluorescent supramolecular polymer for cellular imaging

Supplementary files

Article information

Article type
Research Article
Submitted
01 ፌብሩ 2022
Accepted
22 ፌብሩ 2022
First published
22 ፌብሩ 2022

Mater. Chem. Front., 2022,6, 1021-1025

A new cucurbit[10]uril-based AIE fluorescent supramolecular polymer for cellular imaging

Y. Luo, S. Gan, W. Zhang, M. Jia, L. Chen, C. Redshaw, Z. Tao and X. Xiao, Mater. Chem. Front., 2022, 6, 1021 DOI: 10.1039/D2QM00084A

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