Albumin-mediated extracellular zinc speciation drives cellular zinc uptake†
James P. C.
Coverdale, 
ab
Hugo A.
van den Berg,
c
Hannah E.
Bridgewater,
a
Alan J.
Stewart
d
and
Claudia A.
Blindauer
*a
ab
Hugo A.
van den Berg,
c
Hannah E.
Bridgewater,
a
Alan J.
Stewart
d
and
Claudia A.
Blindauer
*a
Abstract
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
- This article is part of the themed collection: Celebrating 10 years of ChemComm Emerging Investigators
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