Issue 57, 2022

Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

Abstract

The site-selective chemical appendage of multiple functionalities on a native peptide backbone is a highly demanding and complex tool of modern chemical biology. Here, novel NHS-activated acrylates were designed to hold various payloads in a single bioconjugation handle that is able to site-selectively and orthogonally target the N-terminal cysteine of peptides.

Graphical abstract: Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

Supplementary files

Article information

Article type
Communication
Submitted
18 ኤፕሪ 2022
Accepted
20 ጁን 2022
First published
20 ጁን 2022

Chem. Commun., 2022,58, 7928-7931

Multivalent NHS-activated acrylates for orthogonal site-selective functionalisation of peptides at cysteine residues

M. Djaló, M. J. S. A. Silva, H. Faustino, S. N. Pinto, R. Mendonça and P. M. P. Gois, Chem. Commun., 2022, 58, 7928 DOI: 10.1039/D2CC02204D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements