Recent advances in hydride transfer-involved C(sp3)–H activation reactions

Abstract

The hydride transfer reaction, which is characterized by a redox-neutral and step/atom economic process, has emerged as an enabling platform for C(sp³)–H activation with high efficiency. During the past five years, significant advances have been made in new versions of hydride transfer-enabled C(sp³)–H activation, which mainly include the construction of novel scaffolds for cycles, and the intermolecular methods of both hydride transfer and C(sp³)–H functionalization. Herein, we summarize recent progress according to the reaction types categorized into hydride transfer/intramolecular C(sp³)–H functionalization, hydride transfer/intermolecular C(sp³)–H functionalization, and hydride reduction reactions. Furthermore, unsolved scientific problems as well as future directions in this field are also directly indicated. This review covers the period from 2016 to 2020.