Issue 43, 2021

A modular strategy for the synthesis of marine originated meroterpenoid-type natural products

Abstract

A modular strategy for meroterpenoid-type marine natural products has been developed from commercially available (+)-sclareolide using a palladium-catalyzed tandem carbene migratory insertion as one of the key steps. Its applicability is showcased by the formal synthesis of (−)-pelorol and 9-epi-pelorol and the concise total synthesis of (+)-yahazunone and (+)-yahazunol. It is worth noting that the formal synthesis of (−)-pelorol and 9-epi-pelorol was achieved by controlling the reaction sequence of hydrogenation and cyclization.

Graphical abstract: A modular strategy for the synthesis of marine originated meroterpenoid-type natural products

Supplementary files

Article information

Article type
Paper
Submitted
14 ኦገስ 2021
Accepted
08 ኦክቶ 2021
First published
22 ኦክቶ 2021

Org. Biomol. Chem., 2021,19, 9439-9447

A modular strategy for the synthesis of marine originated meroterpenoid-type natural products

H. Wang, X. Nan, H. Li, Z. Cao and Y. Wu, Org. Biomol. Chem., 2021, 19, 9439 DOI: 10.1039/D1OB01598B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements