Issue 41, 2021

Stabilization of liquid active guests via nanoconfinement into a flexible microporous metal–organic framework

Abstract

Liquid active ingredients are typically less stable than their solid analogues and they are also generally associated with storage and handling problems when considered for industrial usage. However, many synthetic and natural active ingredients are liquid or low melting solids under ambient conditions, and formulation or cocrystallization might be helpful to modulate this characteristic. As an alternative, crystalline porous matrices, such as metal–organic frameworks, can be used to encapsulate the guest molecules providing them with a crystalline environment very different to what might be observed in the pure liquid phase, thus stabilizing the active compounds in the solid state. In this work, PUM168, a flexible heteroleptic MOF, has been used to encapsulate three liquid compounds (propofol, carvacrol and menthone). The nanoconfinement of the three guests has been fully investigated via SCXRD in terms of host–guest interactions and framework rearrangement as a function of the guest loading.

Graphical abstract: Stabilization of liquid active guests via nanoconfinement into a flexible microporous metal–organic framework

Supplementary files

Article information

Article type
Paper
Submitted
09 ጁላይ 2021
Accepted
05 ሴፕቴ 2021
First published
06 ሴፕቴ 2021

CrystEngComm, 2021,23, 7262-7269

Stabilization of liquid active guests via nanoconfinement into a flexible microporous metal–organic framework

P. P. Mazzeo, D. Balestri, A. Bacchi and P. Pelagatti, CrystEngComm, 2021, 23, 7262 DOI: 10.1039/D1CE00899D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements