Issue 23, 2020

LiBr-promoted photoredox neutral Minisci hydroxyalkylations of quinolines with aldehydes

Abstract

Photoredox-neutral hydroxyalkylations of quinolines with aldehydes, induced by sustainable visible light under mild conditions, are described. Non-toxic and inexpensive LiBr is found to be the key for the success of the atom-economical Minisci method. Combined with a highly oxidative photocatalyst and visible light irradiation, the bromide additive mediates the H abstraction/acyl radical formation directly from aldehydes. The present mild photoredox neutral protocol provides an important alternative, especially for the challenging Minisci hydroalkylations, as well as a promising approach for atom-economical Minisci reactions with broader N-heterocycle spectra.

Graphical abstract: LiBr-promoted photoredox neutral Minisci hydroxyalkylations of quinolines with aldehydes

Supplementary files

Article information

Article type
Communication
Submitted
02 ጁን 2020
Accepted
22 ጁላይ 2020
First published
22 ጁላይ 2020

Green Chem., 2020,22, 8233-8237

LiBr-promoted photoredox neutral Minisci hydroxyalkylations of quinolines with aldehydes

X. Ji, Q. Liu, Z. Wang, P. Wang, G. Deng and H. Huang, Green Chem., 2020, 22, 8233 DOI: 10.1039/D0GC01872D

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