Issue 14, 2018

Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense

Abstract

Dysohonin A (1), a meroditerpenoid incorporating an unprecedented 6,15,6-fused heterotricyclic ring system, along with three new biogenetically related meroditerpenoids dysohonins B–D (2–4) were isolated from Dysoxylum hongkongense. Their structures with absolute configurations were well established by a combined method. The plausible biosynthetic pathways of 1–4 were proposed. All the compounds exhibited PTP1B inhibitory activities.

Graphical abstract: Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense

Supplementary files

Article information

Article type
Research Article
Submitted
12 ሜይ 2018
Accepted
08 ጁን 2018
First published
13 ጁን 2018

Org. Chem. Front., 2018,5, 2202-2207

Dysohonin A, a meroditerpenoid incorporating a 6,15,6-fused heterotricyclic ring system from Dysoxylum hongkongense

J. Zhao, C. Liu, M. Zhang, J. Li and J. Yue, Org. Chem. Front., 2018, 5, 2202 DOI: 10.1039/C8QO00469B

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