Issue 53, 2018

Single-site labeling of lysine in proteins through a metal-free multicomponent approach

Abstract

We report a chemoselective and site-selective approach that distinguishes one Lys from its multiple copies, N-terminus, and other competitors. The phospha-Mannich protocol works with multiple proteins and installs probes without structural and functional perturbations. It delivers an antibody–drug conjugate with selective anti-proliferative activity towards HER2 expressing SKBR3 breast cancer cells.

Graphical abstract: Single-site labeling of lysine in proteins through a metal-free multicomponent approach

Supplementary files

Article information

Article type
Communication
Submitted
24 ኤፕሪ 2018
Accepted
06 ጁን 2018
First published
07 ጁን 2018

Chem. Commun., 2018,54, 7302-7305

Single-site labeling of lysine in proteins through a metal-free multicomponent approach

M. Chilamari, N. Kalra, S. Shukla and V. Rai, Chem. Commun., 2018, 54, 7302 DOI: 10.1039/C8CC03311K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements