Issue 18, 2018

An S-alkyl thiocarbamate-based biosensor for highly sensitive and selective detection of hypochlorous acid

Abstract

We reported a near-infrared biosensor that features a dihydromethylene blue and an S-alkyl thiocarbamate linker to detect hypochlorous acid in a drastic fluorescence turn-on response. We achieved high sensitivity at the nanomolar level and high selectivity that resolves the interference issue with mercury ions and other transition metal ions. We demonstrated the response mechanism by analysing the released segments, and investigated the imaging capability to detect both exogenous and endogenous hypochlorous acid in living cells.

Graphical abstract: An S-alkyl thiocarbamate-based biosensor for highly sensitive and selective detection of hypochlorous acid

Supplementary files

Article information

Article type
Communication
Submitted
04 ጁን 2018
Accepted
30 ጁላይ 2018
First published
31 ጁላይ 2018

Analyst, 2018,143, 4251-4255

An S-alkyl thiocarbamate-based biosensor for highly sensitive and selective detection of hypochlorous acid

J. Sun and F. Feng, Analyst, 2018, 143, 4251 DOI: 10.1039/C8AN01027G

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