Issue 48, 2016

Macrolactam analogues of macrolide natural products

Abstract

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity. The methods for the synthesis of several lactam analogues of macrolide natural products are highlighted and aspects of their biological properties presented.

Graphical abstract: Macrolactam analogues of macrolide natural products

Article information

Article type
Review Article
Submitted
03 ኦክቶ 2016
Accepted
27 ኦክቶ 2016
First published
27 ኦክቶ 2016

Org. Biomol. Chem., 2016,14, 11301-11316

Macrolactam analogues of macrolide natural products

H. M. Hügel, A. T. Smith and M. A. Rizzacasa, Org. Biomol. Chem., 2016, 14, 11301 DOI: 10.1039/C6OB02149B

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