Issue 84, 2016

Chemodivergent synthesis of multi-substituted/fused pyrroles via copper-catalyzed carbene cascade reaction of propargyl α-iminodiazoacetates

Abstract

A novel cascade reaction of alkynyl-tethered α-iminodiazoacetates has been developed, which provides a general access to both multi-substituted and fused pyrroles in high yields with a broad substrate scope. The γ-imino carbene is proposed as the key intermediate in this divergent reaction and followed by unpresented transformations.

Graphical abstract: Chemodivergent synthesis of multi-substituted/fused pyrroles via copper-catalyzed carbene cascade reaction of propargyl α-iminodiazoacetates

Supplementary files

Article information

Article type
Communication
Submitted
22 ኦገስ 2016
Accepted
27 ሴፕቴ 2016
First published
27 ሴፕቴ 2016

Chem. Commun., 2016,52, 12470-12473

Chemodivergent synthesis of multi-substituted/fused pyrroles via copper-catalyzed carbene cascade reaction of propargyl α-iminodiazoacetates

C. Zhang, S. Chang, L. Qiu and X. Xu, Chem. Commun., 2016, 52, 12470 DOI: 10.1039/C6CC06864B

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