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Issue 23, 2013

Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials

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Abstract

There is a great deal of interest in the development of nanoplatforms gathering versatility and multifunctionality. The strategy reported herein meets these requirements and further integrates a cell-friendly shell in a bio-inspired approach. By taking advantage of a cell mechanism of biomolecule transport using vesicles, we engineered a hybrid biogenic nanoplatform able to encapsulate a set of nanoparticles regardless of their chemistry or shape. As a proof of versatility, different types of hybrid nanovesicles were produced: magnetic, magnetic-metallic and magnetic-fluorescent vesicles, either a single component or multiple components, combining the advantageous properties of each integrant nanoparticle. These nanoparticle-loaded vesicles can be manipulated, monitored by MRI and/or fluorescence imaging methods, while acting as efficient nano-heaters. The resulting assets for targeting, imaging and therapy converge for the outline of a new generation of nanosystems merging versatility and multifunctionality into a bio-camouflaged and bio-inspired approach.

Graphical abstract: Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials

Supplementary files

Article information


Submitted
28 ማርች 2013
Accepted
03 ጁን 2013
First published
06 ጁን 2013

Nanoscale, 2013,5, 11374-11384
Article type
Paper

Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials

A. K. Andriola Silva, R. Di Corato, T. Pellegrino, S. Chat, G. Pugliese, N. Luciani, F. Gazeau and C. Wilhelm, Nanoscale, 2013, 5, 11374 DOI: 10.1039/C3NR01541F

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