Issue 30, 2012
From the journal:

Organic & Biomolecular Chemistry

Synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block from d-glucosevia fermentation†‡

Gulden Camci-Unal,a   Rahman M. Mizanur,a   Yonghai Chaia  and  Nicola L. B. Pohl*b  

* Corresponding authors

a Department of Chemistry, Iowa State University, Ames, IA, USA

b Wilkinson Professor of Interdisciplinary Engineering, Departments of Chemistry and of Chemical and Biological Engineering, and the Plant Sciences Institute, Hach Hall, Iowa State University, Ames, IA, USA
E-mail: npohl@iastate.edu
Fax: (+) 1-515-294-0105

Abstract

Herein we report the first synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block starting from glucose through pathway engineering of Escherichia coli and subsequent chemical modifications to provide an alternative method to produce KDO, found in plant and bacterial oligosaccharides.

Graphical abstract: Synthesis of a 3-deoxy-d-manno-octulosonic acid (KDO) building block from d-glucose via fermentation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2OB25168J
Article type
Paper
Submitted
20 ጃንዩ 2012
Accepted
08 ማርች 2012
First published
16 ኤፕሪ 2012

Org. Biomol. Chem., 2012,10, 5856-5860

Permissions

Request permissions

Synthesis of a 3-deoxy-D-manno-octulosonic acid (KDO) building block from D-glucose via fermentation

G. Camci-Unal, R. M. Mizanur, Y. Chai and N. L. B. Pohl, Org. Biomol. Chem., 2012, 10, 5856 DOI: 10.1039/C2OB25168J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements