Issue 30, 2012

Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs

Abstract

A modular total synthesis of the natural product (+)-varitriol (1) and seven analogs was achieved by using combined coinage metal catalysis. Starting from enynol 13, reagent-controlled introduction of stereogenic centers and efficient center-to-axis-to-center chirality transfer via α-hydroxyallene 5 afforded (+)-varitriol with 6.4% yield over 10 steps.

Graphical abstract: Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs

Supplementary files

Article information

Article type
Paper
Submitted
10 ጃንዩ 2012
Accepted
20 ፌብሩ 2012
First published
13 ማርች 2012

Org. Biomol. Chem., 2012,10, 5965-5970

Combined coinage metal catalysis in natural product synthesis: total synthesis of (+)-varitriol and seven analogs

T. Sun, C. Deutsch and N. Krause, Org. Biomol. Chem., 2012, 10, 5965 DOI: 10.1039/C2OB25069A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements