Issue 31, 2009

Advances in gene delivery through molecular design of cationic lipids

Abstract

This feature article describes the recent developments in the design of cationic lipids and their applications in gene delivery. Various structure–activity investigations explaining the variations in gene transfection efficacies with respect to different molecular structures of the cationic lipids have been discussed. Gene transfer abilities are presented in relation to aggregation properties of different aqueous formulations such as cationic liposomes and surfactant aggregates from various amphiphiles and cationic lipids, as a function of their hydrophobic parts, linkers and head groups.

Graphical abstract: Advances in gene delivery through molecular design of cationic lipids

Article information

Article type
Feature Article
Submitted
12 ጃንዩ 2009
Accepted
13 ሜይ 2009
First published
03 ጁላይ 2009

Chem. Commun., 2009, 4632-4656

Advances in gene delivery through molecular design of cationic lipids

S. Bhattacharya and A. Bajaj, Chem. Commun., 2009, 4632 DOI: 10.1039/B900666B

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