Issue 21, 2023

Carbohydrate–macrocycle conjugates for biomedical applications

Abstract

Carbohydrates are of great importance in a variety of biological processes, including but not limited to, energy production, energy storage, protein recognition, immune response, and macromolecule decoration. Many of the biofunctions of carbohydrates are achieved through a multivalent effect, so the construction of a multivalent carbohydrate system has remained an important topic in glycobiochemistry. Supramolecular macrocycles are characterized by an adjustable cavity, controllable conformation, precise structure, modifiability, and a pre-organized structure. Combined with their recognition and assembly properties, supramolecular macrocycles play an important role in the field of biomedical materials. This review focuses on the synthesis of such conjugates and discusses the biofunctions of carbohydrates and macrocycles, the synergetic contribution of the conjugates, and the perspectives of carbohydrate–macrocycle conjugates.

Graphical abstract: Carbohydrate–macrocycle conjugates for biomedical applications

Article information

Article type
Review Article
Submitted
10 ሜይ 2023
Accepted
06 ጁላይ 2023
First published
11 ጁላይ 2023

Mater. Chem. Front., 2023,7, 5263-5287

Carbohydrate–macrocycle conjugates for biomedical applications

F. Yin, J. Li, B. Shi, K. Zhang, X. Li, K. Wang and D. Guo, Mater. Chem. Front., 2023, 7, 5263 DOI: 10.1039/D3QM00540B

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