Issue 17, 2023

Rational design of amphiphilic BODIPY-based photosensitizers for multimodal imaging-guided phototherapy

Abstract

The design of effcient photosensitisers for cancer theranostics is of great importance, especially for multimodal-imaging-guided synergistic therapy. The key to achieving accurate imaging-guided phototherapy is to balance the energy distribution between fluorescence imaging, photodynamic therapy (PDT) and photothermal therapy (PTT). Herein, we propose a strategy of introducing hydrophilic chains and halogen atoms in boron dipyrromethene (BODIPY), which can self-assemble into J-aggregate nano-micelles in water with free BODIPY molecules in the cavity, enabling both imaging and multiple therapeutics. Remarkably, the degree of J-aggregation of the nanoparticles (NPs) varies under the influence of the steric effects of the 3,5-position group of BODIPY. In particular, BDPN NPs with suitable nano-size, strong NIR-absorption, applicable fluorescence quantum yield (Φf = 3.0%), satisfactory photothermal conversion efficiency (PCE = 54.9%) and favorable singlet oxygen quantum yield (ΦΔ = 40.76%) were proved to completely destroy 4T1 tumors under 808 nm laser irradiation without significant dark cytotoxicity, enabling synergistic PDT/PTT guided by fluorescence/photothermal/photoacoustic imaging. This study provides an emerging strategy for cancer therapy and a novel idea for the future development of new efficient photosensitizers.

Graphical abstract: Rational design of amphiphilic BODIPY-based photosensitizers for multimodal imaging-guided phototherapy

Supplementary files

Article information

Article type
Research Article
Submitted
06 ማርች 2023
Accepted
23 ሜይ 2023
First published
26 ሜይ 2023

Mater. Chem. Front., 2023,7, 3668-3679

Rational design of amphiphilic BODIPY-based photosensitizers for multimodal imaging-guided phototherapy

M. Jiang, J. Zhang, Y. Li, T. Shi, T. Ma, Y. Sun, H. Qiu, Y. Li and S. Yin, Mater. Chem. Front., 2023, 7, 3668 DOI: 10.1039/D3QM00239J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements