Issue 19, 2022

Natural product total synthesis using rearrangement reactions

Abstract

Total synthesis of natural products has been an important pursuit in chemical synthesis due to their fascinating structural complexity and/or interesting biological activities. In most synthetic designs, the rapid construction of the core skeletons, the precise control of stereochemistry, and the identification of suitable synthons are key concerns, which, to a large extent, account for the overall synthetic efficiency. This review will highlight how rearrangement reactions can contribute in addressing these three concerns, thus simplifying the total synthesis campaigns.

Graphical abstract: Natural product total synthesis using rearrangement reactions

Article information

Article type
Review Article
Submitted
01 ጁላይ 2022
Accepted
05 ኦገስ 2022
First published
06 ኦገስ 2022

Org. Chem. Front., 2022,9, 5383-5394

Natural product total synthesis using rearrangement reactions

L. Chen, G. Li and L. Zu, Org. Chem. Front., 2022, 9, 5383 DOI: 10.1039/D2QO01040B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements